Do not take this medicine with any of the following medications:

-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-grapefruit juice
-rifabutin
-rifampin
-Seville oranges
-St. John''s Wort
This medicine may also interact with the following medications:

-certain antibiotics like clarithromycin, erythromycin, telithromycin
-certain medicines for anxiety or sleep
-certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, and voriconazole
-cyclosporine
-digoxin
-tacrolimus

They need to know if you have any of these conditions:

-kidney disease
-liver disease
-an unusual or allergic reaction to ivacaftor, other medicines, foods, dyes, or preservatives
-pregnant or breast-feeding

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
Your vision and blood may be tested before and during use of this medicine.
Tell your doctor or health care professional right away if you have any change in your eyesight.
You may get dizzy. Do not ride a bicycle, drive, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly. This reduces the risk of dizzy or fainting spells. Avoid cough and cold medicines, alcohol, and activities that may make you drowsy or dizzy.

Keep out of the reach of children.
Store at room temperature between 15 to 30 degrees C (59 to 86 degrees F). Throw away any unused medicine after the expiration date.