Do not take this medicine with any of the following medications:

-cisapride
-dronedarone
-pimozide
-thioridazine

This medicine may also interact with the following medications:

-alcohol
-antihistamines for allergy, cough and cold
-certain medicines for anxiety or sleep
-certain medicines for blood pressure, heart disease, irregular heart beat
-certain medicines for depression like amitriptyline, fluoxetine, sertraline, paroxetine
-certain medicines for seizures like phenobarbital, primidone
-general anesthetics like halothane, isoflurane, methoxyflurane, propofol
-medicines that relax muscles for surgery
-methadone
-naltrexone
-narcotic medicines for pain
-other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

They need to know if you have any of these conditions:

-heart disease
-history of irregular or slow heartbeat
-history of lightheadedness, fainting spells
-history of stroke
-if you drink alcohol
-kidney disease
-liver disease
-long QT syndrome
-low levels of calcium, magnesium, or potassium in the blood
-low blood pressure
-an unusual or allergic reaction to lofexidine, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care professional regularly. For this medicine to be most effective you should attend any counseling or support groups that your doctor or health care professional recommends.

You may become more sensitive to narcotics after a period of not using them. This may increase your risk of overdose and death if you start using them again.

Be alert for any symptoms of low blood pressure or slow heart rate, such as dizziness and feeling faint or lightheaded at rest or after standing quickly from a sitting or lying position. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Avoid becoming dehydrated or overheated, which may increase the risk for low blood pressure and fainting. If you experience symptoms of low blood pressure or slow heart rate, do not take your next dose of this medicine until you have talked to your healthcare provider.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Alcohol may increase drowsiness or dizziness.

Keep out of the reach of children.

Store between 15 and 30 degrees C (77 and 86 degrees F). Keep this medicine in the original container. Keep away from heat and moisture. Throw away any unused medicine after the expiration date.