Warnings


What may interact with LUPKYNIS?

Do not take this medicine with any of the following medicines:

-ceritinib
-certain antivirals for HIV or hepatitis like atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, grazoprevir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir
-certain medicines for fungal infections like fluconazole, ketoconazole, itraconazole, posaconazole, or voriconazole
-chloramphenicol
-cidofovir
-cisapride
-clarithromycin
-conivaptan
-cyclophosphamide
-dronedarone
-grapefruit juice
-idelalisib
-lefamulin
-lonafarnib
-mifepristone
-nefazodone
-other medicines that prolong the QT interval (an abnormal heart rhythm)
-pimozide
-ribociclib
-telithromycin
-thioridazine
-tucatinib
This medicine may also interact with the following medicines:

-bosentan
-carbamazepine
-certain medicines for cholesterol like atorvastatin, lovastatin, simvastatin, rosuvastatin
-cimetidine
-diltiazem
-efavirenz
-erythromycin
-fluvoxamine
-live virus vaccines
-phenobarbital
-phenytoin
-rifampin
-St. John''s wort
-verapamil

What should I tell my health care provider before I take LUPKYNIS?

They need to know if you have any of these conditions:

-heart disease
-high blood pressure
-immune system problems
-infection
-irregular heartbeat or rhythm
-kidney disease
-liver disease
-recent or upcoming vaccination
-an unusual or allergic reaction to voclosporin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using LUPKYNIS?

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.
This medicine may increase your risk of getting an infection. Call your health care provider for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
Avoid taking medicines that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your health care provider. These medicines may hide a fever.
Do not become pregnant while taking this medicine. Women should inform their health care provider if they wish to become pregnant or think they might be pregnant. There is potential for serious harm to an unborn child. Talk to your health care provider for more information. Do not breast-feed an infant while taking this medicine.
Talk to your health care provider about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.

Where should I keep my medicine?

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original packaging until you are ready to take it. Throw away any unused medicine after the expiration date.