Do not take this medicine with any of the following medications:

-artemether
-certain antivirals for HIV or hepatitis like atazanavir, cobicistat, daclatasvir, darunavir, doravirine, elbasvir; grazoprevir, elvitegravir, fostemsavir, lopinavir, nelfinavir, ritonavir, or tipranavir
-certain medicines for fungal infections like isavuconazonium, ketoconazole, itraconazole, or posaconazole
-lorlatinib
-lurasidone
-praziquantel
-ranolazine
This medicine may also interact with the following medications:

-warfarin

They need to know if you have any of these conditions:

-liver disease
-an unusual or allergic reaction to mitotane, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care professional for regular checks on your progress. You may need blood work done while you are taking this medicine. If you are going to need surgery, be sure to tell your doctor before the procedure is scheduled. Do not stop taking except on your doctor''s advice.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Tell your doctor immediately if you get a serious injury, serious infection, or any serious illness requiring a hospital visit or emergency care, including trauma. Mitotane should be stopped until you recover.
Try to avoid people who are sick during your treatment. Do not have any vaccinations without your doctor''s approval and avoid anyone who has recently had oral polio vaccine.
Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. The use of effective birth control is advised. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date. Talk to your health care provider about how to dispose of this medicine.