Do not take this medicine with any of the following medications:

-cisapride
-dronedarone
-fingolimod
-pimozide
-saquinavir
-thioridazine
This medicine may also interact with the following medications:

-alemtuzumab
-certain antivirals for HIV or hepatitis
-certain medicines for blood pressure, heart disease, irregular heart beat
-certain medicines for fungal infections like ketoconazole, itraconazole, or posaconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-digoxin
-live virus vaccines
-medicines that lower your chance of fighting infection
-modafinil
-other medicines that prolong the QT interval (an abnormal heart rhythm)
-rifampin

They need to know if you have any of these conditions:

-cancer
-diabetes
-eye disease
-heart disease
-high blood pressure
-immune system problems
-infection especially a viral infection such as chickenpox, cold sores, or herpes
-irregular heartbeat or rhythm
-liver disease
-low blood counts (white cells, platelets, or red blood cells)
-lung disease
-recent or upcoming vaccine
-stroke
-an unusual or allergic reaction to siponimod, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.
In some patients, this medicine may cause a serious brain infection that may cause death. If you have any problems seeing, thinking, speaking, walking, or standing, tell your health care provider right away. If you cannot reach your health care provider, urgently seek other source of medical care.
Your vision may be tested before and during use of this medicine. Tell your health care provider right away if you have any change in your eyesight.
You may need blood work done while you are taking this medicine.
This medicine may increase your risk of getting an infection. Call your health care provider for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
Talk to your health care provider if you have not had chickenpox or the vaccine for chickenpox.
This medicine can decrease the response to a vaccine. If you need to get vaccinated, tell your health care provider if you have received this medicine within the last 4 weeks. Extra booster doses may be needed. Talk to your health care provider to see if a different vaccination schedule is needed.
If you stop taking this medicine, your MS symptoms may get worse. You may have more weakness, trouble using your arms or legs, or changes in balance. Talk to your health care provider right away if your symptoms get worse.
Do not become pregnant while taking this medicine. Women must use a form of birth control while taking this medicine. Women will also need to take it for 10 days after stopping the medicine. There is potential for serious harm to an unborn child. Tell your health care provider right away if you think you might be pregnant.
This medicine can make you more sensitive to the sun. Keep out of the sun, if you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not use sun lamps or tanning beds/booths.
Talk to your health care provider about your risk of cancer. You may be more at risk for certain types of cancer if you take this medicine.

Keep out of the reach of children and pets.
You will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date.