Do not take this medicine with any of the following medications:

-certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
-cisapride
-dronedarone
-halofantrine
-pimozide
-quinidine
-quinine
-thioridazine

This medicine may also interact with the following medications:

-chloroquine
-certain medicines for depression, anxiety, or psychotic disturbances
-certain medicines for irregular heart beat
-certain medicines for seizures like valproic acid, carbamazepine, phenobarbital, phenytoin
-other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide, ziprasidone
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
-propranolol
-typhoid vaccine

They need to know if you have any of these conditions:

-anxiety or panic attacks
-confusion
-depression or history of mental problems including anxiety disorder, schizophrenia, paranoia (mistrust towards others), or psychosis
-heart disease
-liver disease
-restlessness
-seizures (epilepsy or convulsions)
-an unusual or allergic reaction to mefloquine, hydroxymefloquine, quinidine, quinine, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your doctor or health care professional if your symptoms do not start to get better in a few days. If you are taking this medicine for a long time, visit your doctor or health care professional for regular checks. If you notice any changes in your vision see your eye doctor for an eye exam.

If you get a fever during or after you start taking this medicine, do not treat yourself. Contact your doctor or health care professional immediately.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

While in areas where malaria is common, you should take steps to prevent being bit by mosquitos. This includes staying in air-conditioned or well-screened rooms to reduce human-mosquito contact, sleep under mosquito netting, preferably one with pyrethrum-containing insecticide, wear long-sleeved shirts or blouses and long trousers to protect arms and legs, apply mosquito repellents containing DEET to uncovered areas of skin, and use a pyrethrum-containing flying insect spray to kill mosquitos.

If you are currently taking or have taken this medicine in the past 3 weeks, you should not take halofantrine (another malarial drug). Dangerous heart side effects may occur. Talk to your health care provider.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.