What side effects may I notice from receiving Mekinist?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-blurred vision
-cough
-diarrhea
-eye pain
-feeling faint or lightheaded
-rash, fever, and swollen lymph nodes
-redness, blistering, peeling, or loosening of the skin, including inside the mouth
-severe headaches
-signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
-signs and symptoms of a blood clot such as breathing problems; changes in vision; chest pain; severe, sudden headache; pain, swelling, warmth in the leg; trouble speaking; sudden numbness or weakness of the face, arm or leg
-signs and symptoms of heart failure like breathing problems; fast, irregular heartbeat; sudden weight gain; swelling of the ankles, feet, hands; unusually weak or tired
-signs and symptoms of high blood sugar such as dizziness; dry mouth; dry skin; fruity breath; nausea; stomach pain; increased hunger or thirst; increased urination
-stomach pain
-unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-decreased appetite
-joint pain
-muscle pain
-nausea, vomiting

This list may not describe all possible side effects for Mekinist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.