Menopur Uses

Menopur is used to treat female infertility that is not caused by primary ovarian failure. It stimulates the development of multiple follicles and pregnancy as part of an assisted reproductive technology (ART) cycle.

There may be other uses of Menopur—your doctor or pharmacist can give you further drug information.

Menopur Mechanism of Action

Menopur contains two hormones that are made naturally in the body by the pituitary gland - follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones trigger follicular growth and maturation in the ovaries in women who do not have primary ovarian failure. In other words, Menopur contains hormones that help the ovaries prepare eggs for ovulation.

Menopur Doses

Each vial of Menopur contains 75 International Units (IU) of follicle-stimulating hormone (FSH) and 75 International Units (IU) of luteinizing hormone (LH). 

Dosing of Menopur for patients undergoing IVF is done in a stepwise fashion and is individualized for each patient. Women who have received a GnRH agonist for pituitary suppression typically receive an initial Menopur dose of 225 IU daily for 7 to 20 days. 

Menopur may be given with Bravelle (urofollitropin for injection), in which case, the combined initial dose should be no more than 225 IU (150 IU Menopur and 75 IU Bravelle or 75 IU Menopur and 150 IU Bravelle). The maximum daily dose of Menopur alone or combination Menopur and Bravelle is 450 IU per day. The maximum treatment duration is 20 days. Your healthcare provider will prescribe the lowest effective dose of Menopur.

Treatment is started on day 2 or 3 of the menstrual cycle with 225 IU Menopur injected subcutaneously daily. The dose can be adjusted after 5 days based on response as indicated by follicular growth seen on ultrasound examination and serum estradiol levels. Dosage adjustments are not made more frequently than every 2 days or by more than 150 IU at one time. Treatment is continued until follicular maturation is seen, at which time human chorionic gonadotropin (hCG) is administered to induce ovulation. However, hCG is not administered if there is evidence of ovarian hyperstimulation syndrome (OHSS).