Methotrexate

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Aug 05, 2022

Common Questions


Common Questions about Methotrexate


Is methotrexate a safe drug during pregnancy?

No, methotrexate is not safe for pregnant women or during pregnancy. It can cause harm to or death of the fetus. It is essential to use a reliable method of birth control for both men and women. Pregnancy must be avoided for a minimum of 3 months for men and 6 months for women after the final dose.



Should live vaccines be avoided while taking methotrexate?

Yes, live vaccines like measles, mumps, and rubella should not be received while taking methotrexate. Because methotrexate impairs your immune system, the live viruses in these vaccines may harm you.



How long does it take for methotrexate to work for rheumatoid arthritis?

Within 3 to 6 weeks, methotrexate can begin treating rheumatoid arthritis, and symptoms improve over the following three months. Do not discontinue taking methotrexate without consulting your doctor.



Why should a folate supplement be taken with methotrexate?

Taking methotrexate can reduce levels of folate in your body. Folate deficiency can cause symptoms such as stomach pain, reduced blood cell counts, muscle weakness, fatigue, mouth sores, liver toxicity, and nervous system symptoms. Taking a folic acid supplement will help combat these side effects. Ask your doctor if this is right for you.



How often are lab tests required while taking methotrexate?

You will undergo a complete check-up and blood tests every one to two weeks when you first begin treatment. This is done to see how well methotrexate is working and to see if any side effects are occurring. Depending on the findings of your tests, your doctor may change the dose of methotrexate you are taking. You'll have check-ups and blood tests every two to three months once you and your doctor have established the ideal dosage and your medication is working.



What is the price of methotrexate without insurance?

Without insurance, methotrexate can be as high as $78.79, but with a free BuzzRx prescription discount coupon, you could pay as low as $15.93 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any prescription drugs—whether you have insurance or not.



What is the price of methotrexate with insurance?

Ask your pharmacist or insurance provider for your copay price on methotrexate—copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins.

You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for methotrexate. When using the BuzzRx lookup tool to find the price of your medicine, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not.