Methotrexate Uses

Methotrexate is an antimetabolite agent used to treat many types of cancers, severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.

There may be other uses of methotrexate—your pharmacist or doctor can give you further drug information.

Methotrexate Mechanism of Action

Methotrexate works by blocking DNA and preventing the growth of new cancer cells. Methotrexate works by slowing down the growth of skin cells and stops scale formation in psoriasis. Methotrexate works in rheumatoid arthritis by reducing the activity of the immune system. 

Methotrexate Doses

Methotrexate is available as a 2.5 mg tablet,1g/vial as a powder for injection, and 25 mg/ml injection solution.

Certain cancers: The methotrexate dosage differs for each individual and depends on the type of cancer, body surface area, ongoing treatments, and many other factors. The dose is usually only taken once per week. 

Rheumatoid arthritis: The recommended starting dosage is 7.5 mg orally once weekly with escalation to achieve an adequate response. The maximum dosage is 20 mg once weekly.

Juvenile Rheumatoid Arthritis: Methotrexate doses in pediatric patients are given depending on their body surface area. The recommended starting dose is usually 10 mg/m² given once weekly with escalation to achieve optimal response. The maximum dose is 30 mg/m²/week.

Psoriasis: The recommended dose is 10 to 25 mg orally once weekly until an adequate response is achieved. The maximum recommended dose is 30 mg per week.