Do not take this medicine with any of the following medications:
-antifungal drugs like fluconazole, itraconazole, ketoconazole posaconazole, or voriconazole
-certain antibiotics like erythromycin, clarithromycin, and troleandomycin
-cocaine
-conivaptan
-dexfenfluramine
-ephedrine
-feverfew
-grapefruit juice
-imatinib
-isoproterenol
-medicines called nitrates like isosorbide and nitroglycerin
-medicines for colds, flu, or breathing difficulties like phenylephrine and pseudoephedrine
-medicines for HIV or AIDS called protease inhibitors, delavirdine, efavirenz, nelfinavir
-medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan
-midodrine
-nefazodone
-other ergot alkaloids like bromocriptine, cabergoline, dihydroergotamine, ergoloid mesylates, ergonovine, methylergonovine, and methysergide

This medicine may also interact with the following medications:
-clotrimazole
-fluoxetine
-fluvoxamine
-medicines for high blood pressure, especially beta-blockers
-metronidazole
-nicotine
-zileuton

They need to know if you have any of these conditions:
-heart or blood vessel disease
-high blood pressure
-infection
-kidney disease
-liver disease
-poor circulation
-an unusual or allergic reaction to caffeine, ergotamine, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Check with your doctor or health care professional if you do not get relief from your headaches after using this medicine. You may need to be changed to a different kind of medicine to treat your migraines.

This medicine decreases the circulation of blood to your skin, fingers, and toes. You may get more sensitive to the cold. Elderly patients are more likely to feel this effect. Dress warmly and avoid long exposure to the cold.

This medicine contains caffeine. Limit your intake of caffeinated beverages on the days that you use this medicine.

If you take migraine medicines for 10 or more days a month, your migraines may get worse. Keep a diary of headache days and medicine use. Contact your healthcare professional if your migraine attacks occur more frequently.

Keep out of the reach of children.

Store below 25 degrees C (77 degrees F). Keep medication in sealed foil until just prior to use. Protect from moisture. Throw away any unused medicine after the expiration date.