This medicine may interact with the following medications:

-darbepoetin alfa
-epoetin alfa

They need to know if you have any of these conditions:

-cancer
-blood clotting disorders
-heart disease
-hemoglobin level of 12 g/dl or greater
-high blood pressure
-history of stroke or blood clots
-low levels of iron, folate, or vitamin B12
-seizures
-an unusual or allergic reaction to Methoxy polyethylene glycol-epoetin beta, mannitol, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your prescriber or health care professional for regular checks on your progress and for the needed blood tests and blood pressure measurements. It is especially important for the doctor to make sure your hemoglobin level is in the desired range, to limit the risk of potential side effects and to give you the best benefit. Keep all appointments for any recommended tests. Check your blood pressure as directed. Ask your doctor what your blood pressure should be and when you should contact him or her.

As your body makes more red blood cells, you may need to take iron, folic acid, or vitamin B supplements. Ask your doctor or health care provider which products are right for you. If you have kidney disease continue dietary restrictions, even though this medication can make you feel better. Talk with your doctor or health care professional about the foods you eat and the vitamins that you take.

Keep out of the reach of children.

If you are using this medicine at home, you will be instructed on how to store this medicine. Store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). If a refrigerator is unavailable, the prefilled syringes may be stored at room temperature (up to 77 degrees F [25 degrees C]) for up to 30 days. Vials may be stored at room temperature for up to 7 days. Throw away any unused portion. Do not freeze or shake. Protect from light. Throw away unused medicine after the expiration date on the label.