Do not take this medicine with any of the following medications:

-certain antiviral medicines for HIV or AIDS
-certain medicines for fungal infections like ketoconazole, itraconazole, posaconazole, and voriconazole
-chloramphenicol
-clarithromycin
-conivaptan
-dalfopristin; quinupristin
-idelalisib
-mifepristone
-nefazodone
-telithromycin

This medicine may also interact with the following medications:

-bevacizumab
-carbamazepine
-diltiazem
-erythromycin
-grapefruit juice
-methylnaltrexone
-naloxone
-naltrexone
-rifampin
-St. John''s Wort
-verapamil

They need to know if you have any of these conditions:

-cancer or tumor in abdomen, intestine, or stomach
-diverticulitis
-history of bowel blockage
-inflammatory bowel disease
-kidney disease
-liver disease
-recent surgery on the stomach or intestine
-stomach or intestine problems
-taking bevacizumab
-an unusual or allergic reaction to naloxegol, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor for regular check ups. Tell your doctor if your symptoms do not get better or if they get worse. If you develop unusually persistent or worsening abdominal pain, stop taking your medicine and seek medical attention.

You may have symptoms of opioid withdrawal during treatment with this medicine. Symptoms include sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Tell your health care provider if you have any of these symptoms. Also, if you take methadone to treat your pain, you may be more likely to have stomach pain and diarrhea compared to people who do not take methadone. If you take too much of this medicine, call your healthcare provider or go to the nearest emergency room right away.

Keep out of the reach of children.

This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law. Follow the directions in the MedGuide.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.