This medicine may interact with the following medications:

-certain medicines for diabetes, like insulin, glipizide, or glyburide
-certain medicines that treat or prevent blood clots like warfarin
-cyclosporine
-female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
-theophylline

They need to know if you have any of these conditions:

-bone marrow problems
-cancer
-diabetes
-history of pancreatitis
-high triglyceride levels
-immune system problems
-liver disease
-low blood counts, like low white cell counts
-obesity not caused by a congenital leptin deficiency
-pancreatic disease
-signs of infection
-swollen lymph nodes
-an unusual or allergic reaction to metreleptin, other medications, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take the medicine.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine. Learn the symptoms of low and high blood sugar and how to manage them.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

Do not stop taking except on your doctor''s advice.

Keep out of the reach of children.

You will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date on the label.