Do not take this medicine with any of the following medications:

-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
-elagolix
-cisapride
-dronedarone
-pimozide
-thioridazine
This medicine may also interact with the following medications:

-certain antibiotics such as erythromycin, clarithromycin, or telithromycin
-certain antivirals for HIV or hepatitis
-certain medicines for cancer treatment
-certain medicines for fungal infections such as ketoconazole, itraconazole, or posaconazole
-certain medicines for seizures such as carbamazepine, phenobarbital, phenytoin
-corticosteroids like hydrocortisone, prednisone, and prednisolone
-cyclosporine
-grapefruit juice
-medicines for diabetes
-mifepristone
-other medicines that prolong the QT interval (abnormal heart rhythm)
-raloxifene
-rifampin
-St. John''s Wort
-tamoxifen
-thyroid hormones
-tranexamic acid
-tricyclic antidepressants
-verapamil
-warfarin

They need to know if you have any of these conditions:

-blood vessel disease or blood clots
-breast, cervical, endometrial, or uterine cancer
-diabetes (high blood sugar)
-gallbladder disease
-heart disease
-high blood pressure
-high cholesterol
-kidney disease
-liver disease
-lupus
-migraine headaches
-mental health disease
-osteoporosis, weak bones
-porphyria
-smoke tobacco cigarettes
-stroke
-suicidal thoughts, plans, or attempt or a previous suicide attempt by you or a family member
-unexplained vaginal bleeding
-an unusual or allergic reaction to relugolix, estrogens, progestins, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. You will need a regular breast and pelvic exam while on this medicine. It may take several months to see improvement in your condition.
You may have a change in bleeding pattern or irregular periods. Many females stop having periods while taking this drug.
Do not become pregnant while taking this medicine. Women must use a non-hormonal form of birth control while taking this medicine. Women will also need to take it for 1 week after stopping the medicine. There is potential for serious harm to an unborn child. Tell your health care provider right away if you think you might be pregnant.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your provider if you feel you are retaining fluid.
Using this medicine for a long time may weaken your bones. The risk of bone fractures may be increased. Talk to your health care provider about your bone health.
If you are going to need surgery or other procedure, tell your health care provider that you are using this medicine.

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Get rid of any unused medicine after the expiration date on the label.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, empty the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.