Warnings
Nabumetone Risks, Warnings, and Complications
Nabumetone can cause or worsen health problems in some people. Talk to your doctor or pharmacist about other treatments for arthritis if you are at a higher risk of adverse reactions or serious side effects from this medication. Some of the risks of taking nabumetone include:
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Precautions Before Starting Nabumetone
Tell your doctor if you have ever had an allergic reaction to nabumetone, any of the active or inactive ingredients in nabumetone tablets, other nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen (Advil, Motrin), or naproxen (Aleve, Naprosyn), or any other medications. Your pharmacy can give you a list of ingredients.
Give your doctor and pharmacist a complete list of your medications, including prescription medications, over-the-counter medicines, vitamins, nutritional supplements, and herbal products. This can help avoid possible drug interactions between nabumetone and your other medicines.
Nabumetone may not be right for people with certain medical conditions. Give your doctor a complete medical history. Be sure to mention if you have asthma, nasal polyps, stuffy or runny nose, edema (swelling), heart failure, impaired renal function (kidney disease), or liver disease.
Tell your health care professional if you are pregnant, could be pregnant, plan to get pregnant, or breast feeding.
Precautions During Use of Nabumetone
Keep all your healthcare appointments during nabumetone therapy. Your doctor may start you on a low dose and gradually increase the dose of nabumetone. Follow your doctor’s dosing instructions carefully.
Nabumetone can increase the sensitivity of your skin to sunlight. Avoid sun exposure as much as possible. Wear protective clothing and use sunscreen to protect your skin.
Tell your doctor if you become pregnant while on this medication.
Tell all your healthcare providers you are on nabumetone, especially before any procedure, including dental procedures.
Nabumetone Drug Interactions
Other drugs can affect how nabumetone works. Possible interactions with certain medications can increase the risk of severe adverse effects. Some of the medications that can have interactions with nabumetone include:
- Anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven)
- Aspirin and other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn)
- Oral steroids such as methylprednisolone (Medrol), dexamethasone and prednisone (Rayos)
- Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), citalopram (Celexa), paroxetine (Brisdelle, Paxil, Pexeva), fluvoxamine (Luvox), and sertraline (Zoloft)
- Serotonin norepinephrine reuptake inhibitors (SNRIs) such as venlafaxine (Effexor XR), desvenlafaxine (Khedezla, Pristiq) and duloxetine (Cymbalta)
- Angiotensin-converting enzyme (ACE) inhibitors, for example, lisinopril (in Zestoretic), enalapril (Vasotec, in Vaseretic), benazepril (Lotensin, in Lotrel), fosinopril, captopril, trandolapril (Mavik, in Tarka), ramipril (Altace), quinapril (Accupril, in Quinaretic), moexipril (Univasc), and perindopril (Aceon, in Prestalia)
- Angiotensin receptor blockers (ARBs), for example, irbesartan (Avapro, in Avalide), candesartan (Atacand, in Atacand HCT), telmisartan (Micardis, in Micardis HCT, in Twynsta), losartan (Cozaar, in Hyzaar), eprosartan (Teveten), olmesartan (Benicar, in Benicar HCT, in Azor, in Tribenzor), and valsartan (in Exforge HCT)
- Diuretics or water pills
- Oral diabetes medications
- Psychiatric medications such as lithium (Lithobid)
- Anticonvulsants such as phenytoin (Dilantin, Phenytek)
- Cancer drugs such as methotrexate (Rasuvo, Otrexup, Trexall)
Give your doctor or pharmacist a complete list of your medications, including prescription drugs, nonprescription drugs, dietary supplements, and herbal remedies. Also, tell your healthcare professional if you smoke, drink alcohol, or use recreational drugs because some of these substances can cause serious health complications when used with prescription medications.
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