How should I take ondansetron hydrochloride?

Take ondansetron exactly per your doctor’s dosing instructions. Follow all directions on the prescription label and any medication guides if provided. Never take a larger or smaller amount than the prescribed or recommended dose.

Ondansetron can be taken with or without food.

The first dose is usually taken 30 minutes before starting chemotherapy, radiation, or induction on anesthesia for surgery. 

For chemotherapy or radiation that is highly vomiting-inducing, follow your doctor’s instructions on how to take ondansetron carefully when you’re at home.

Take the regular oral ondansetron tablets with a full glass of water. 

For the orally disintegrating tablets (ondansetron ODT or Zofran ODT):

• Keep all the tablets inside the blister pack until you are ready to take one. Open the package and peel the foil carefully, do not push these tablets through the foil as they may get damaged. 
• Ensure your hands are dry before you handle an orally disintegrating tablet, as moisture can disintegrate it.
• Do not swallow whole. Place the orally disintegrating tablet on your tongue and let it dissolve entirely without chewing. 
• Swallow several times as the tablet dissolves. You may drink some water after the tablet dissolves to help swallow it. 

For the oral soluble film (Zuplenz):

• Keep the film in the pouch until you are ready to use it
• Do not chew or swallow the film 
• Make sure your hands are dry; tear the pouch carefully along the edge and remove the oral soluble film from it.
• Once removing the film from the pouch, place it on top of the tongue, where it dissolved in 4 to 20 seconds. 
• Swallow several times as the film dissolves. You may drink some water to help the swallowing, but it is not required. 
• Wash your hands after handling the oral soluble film

If you are using the liquid form of ondansetron for you or your child, follow the doctor’s dosing instructions and measure liquid medicine with the dosing syringe provided. Do not use household items such as kitchen spoons. 

Missed dose: Take the missed dose as soon as you remember it. However, if it is almost time for the next dose of ondansetron, skip the missed dose and continue your regular dosing schedule. Do not double the dose or take more than prescribed to make up for the missed dose.

Storage: Keep the medication in its original container or blister packs; keep it tightly closed, out of reach of children, pets, and other people. Like any other medications dispensed only with prescriptions, ondansetron should not be shared with anyone. Many people store their medications in the bathroom; this is not recommended due to moisture and heat.

Unused medications: Like other prescription medications, do not consume ondansetron (Zofran) after expiration. This medication is a prescription drug that is intended for your use only. Unneeded medication should be disposed of appropriately to prevent children, pets, and other people from getting to it. Your local pharmacy can provide information about medication drug take-back programs. You can also learn more about proper medication disposal.

NOTE: This sheet is a summary and may not contain all possible information. If you have more questions or concerns about ondansetron, talk to your pharmacist or doctor to ensure that this information applies to you or your family member.

Discounted prices for ondansetron hydrochloride (Zofran)
 start at $16.07.

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