Do not take this medicine with any of the following medications:

-artemether; lumefantrine
-boceprevir
-cobicistat; elvitegravir; emtricitabine; tenofovir
-cobicistat; elvitegravir; emtricitabine; tenofovir alafenamide
-dasabuvir; ombitasvir; paritaprevir; ritonavir
-emtricitabine; rilpivirine; tenofovir
-lurasidone
-nifedipine
-ombitasvir; paritaprevir; ritonavir
-praziquantel
-ranolazine
-rilpivirine

This medicine may also interact with the following medications:

-certain antibiotics like clarithromycin, erythromycin, telithromycin
-certain medicines for depression, anxiety, or sleep
-certain medicines for diabetes, like glipizide or repaglinide
-certain medicines for immunosuppression like cyclosporine, everolimus, sirolimus, or tacrolimus
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-certain medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
-certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
-digoxin
-female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
-grapefruit juice
-ibuprofen
-montelukast
-rifabutin
-rifampin
-St. John''s Wort
-steroid medicines like prednisone or methylprednisolone
-warfarin

They need to know if you have any of these conditions:

-kidney disease
-liver disease
-an unusual reaction to lumacaftor, ivacaftor, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Your vision and blood may be tested before and during use of this medicine.

Tell your doctor or health care professional right away if you have any change in your eyesight.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To avoid dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older person. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Keep out of the reach of children.

Store at room temperature between 20 to 25 degrees C (68 to 77 degrees F). Throw away any unused medicine after the expiration date.