-amiodarone
-bosentan
-carbamazepine
-certain medicines for fungal infections like ketoconazole, itraconazole, fluconazole, and voriconazole
-certain medicines for HIV or hepatitis
-estrogens
-glyburide
-griseofulvin
-mitotane
-modafinil
-omeprazole
-phenobarbital
-phenytoin
-primidone
-raloxifene
-rifampin
-St. John''s wort
-tamoxifen
-toremifene
-warfarin

They need to know if you have any of these conditions:

-cancer, such as breast, uterine, or other cancer
-heart disease
-history of blood clots
-history of stroke
-history of vaginal bleeding
-liver disease
-premenopausal
-smoke tobacco
-an unusual or allergic reaction to ospemifene, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine. You are strongly advised not to smoke.

This medicine does not prevent hot flashes. It may cause hot flashes in some patients.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take with this medicine. You should know, however, that taking a progestin may have additional health risks. You should discuss the use of these medicines with your health care professional to determine the benefits and risks for you.

If you are going to have surgery, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.

If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.