Oxycodone-Acetaminophen Side Effects

Possible side effects of oxycodone and acetaminophen are listed below. Call your doctor for medical advice if they are severe or persist after a few days.

• Drowsiness
• Headache
• Dry mouth
• Flushing
• Abdominal pain
• Mood changes

Some of the adverse effects of oxycodone and acetaminophen are more serious. Call your doctor right away or seek emergency medical help if you develop the following serious symptoms:

• Fast, slow, or irregular heartbeat
• Fever, sweating, shivering, confusion, agitation, hallucinations, fast heartbeat, loss of coordination, severe muscle aches, muscle stiffness, muscle twitching, nausea, vomiting, diarrhea
• Nausea, vomiting, decreased appetite, weakness, lightheadedness
• Severe skin reaction with a skin rash, peeling or blistering skin, hives, itching
• Swelling of the eyes, face, lips, tongue, throat, hands, feet, lower legs, or ankles
• Difficulty breathing or swallowing
• Chest pain
• Hoarseness
• Erectile dysfunction (difficulty achieving or keeping an erection)
• Irregular menstruation
• Low libido (decreased sexual desire)
• Seizures (convulsions)
• Extreme sleepiness
• Dizziness when changing positions (from lying or sitting to standing)

The above list may not include all the potential side effects of oxycodone and acetaminophen. Contact your healthcare provider if your side effects are unusual or severe or they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Oxycodone and acetaminophen Overdose: In case of an overdose of oxycodone-acetaminophen, call your doctor immediately. You can also call your local poison control center, provincial poison control center, or the national poison control center at 1-800-222-1222.

Overdose symptoms may include difficulty breathing, slowed or stopped breathing, excessive drowsiness, limb weakness, cold and clammy skin, changes in pupil size (the black dot in the eyes), and unresponsiveness.

Talk to your healthcare provider about having a rescue medication called naloxone (Narcan) available if you or someone in your household takes an opioid pain medication such as oxycodone-acetaminophen. This medication can reverse the potentially fatal effects of an opioid overdose.

Source: FDA