Polytrim

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Mar 22, 2023

Warnings

Polytrim (POLYMYXIN B / TRIMETHOPRIM) Risks, Warnings, and Complications

Polytrim ophthalmic solution can cause serious problems in some people. Check with your doctor or pharmacist about other treatment options for bacterial eye infections if you are at increased risk of complications from Polytrim. Some of the risks of Polytrim use include:

ALLERGIC REACTIONS: Very rarely, people develop an allergic reaction to Polytrim (polymyxin B and trimethoprim ophthalmic solution). Stop using the medicine and call your doctor for medical advice if you notice a rash, redness, itching, or swelling in the eyes or other parts of the face.
NEW INFECTION WITH PROLONGED USE: Using Polytrim for longer than prescribed can lead to a new bacterial or fungal infection. Use this medication only as long as your doctor tells you. Tell your doctor if you notice any new symptoms or your original symptoms persist after using Polytrim for the prescribed period.

Precautions Before Starting Polytrim (POLYMYXIN B / TRIMETHOPRIM)

Tell your doctor if you have had an allergic reaction to polymyxin B, trimethoprim, any of the active or inactive ingredients in Polytrim eye drops, or any other drugs. Your pharmacy can give you a list of ingredients.

Tell your doctor if you have a medical condition. Polytrim eye drops may not be right for people with certain health conditions.

Give your doctor or pharmacist a complete list of your medications, including prescription drugs, nonprescription medicines, other eye drops, vitamins, supplements, and herbal products. This can help avoid possible interactions between Polytrim and your other medicines.

Tell your doctor if you are pregnant, could be pregnant, are planning a pregnancy, or are breast feeding.

Precautions During Use of Polytrim (POLYMYXIN B / TRIMETHOPRIM)

Use Polytrim only in the eye. This medicine is not for swallowing or injection.

Do not wear contact lenses if you have bacterial conjunctivitis and are using antibiotic eye drops to treat it.

You should know that conjunctivitis spreads easily. Wash your hands frequently, especially after touching your eyes. Once your infection is treated, replace eye makeup, contact lenses, or anything else that touched your eyes.

Keep all your healthcare appointments while taking Polytrim. Your doctor may want to order certain lab tests and monitor you for adverse reactions.

If you are using other eye drops, apply them at least 10 minutes away from Polytrim to give your eye time to absorb each medicine.

Tell your health care professional if you become pregnant while on Polytrim.

Polytrim (POLYMYXIN B / TRIMETHOPRIM) Drug Interactions

Using Polytrim eye drops with certain other medicines can affect how the medicines work. Possible interactions between Polytrim and other medicines can also increase the risk of severe adverse events. Your doctor may change the dose of your medications and/or monitor you carefully for possible side effects if there are known interactions between Polytrim and your other medicines.

Give your doctor or pharmacist a complete list of your medications, including prescription drugs, non-prescription medicines, eye drops, dietary supplements, and herbal remedies. Also, tell your healthcare provider if you smoke, drink alcohol, or use recreational drugs because some of these substances can cause serious health complications when used with prescription and over-the-counter medicines.

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