Prednisolone Sodium Phosphate Uses

Prednisolone sodium phosphate is used to treat a wide range of conditions as follows: 

• Endocrine disorders such as adrenal insufficiency, congenital adrenal hyperplasia, nonsuppurative thyroiditis, and hypercalcemia associated with cancer
• Allergic-type reactions such as asthma, contact dermatitis, atopic dermatitis, and hypersensitivity reactions
• Skin diseases such as pemphigus, severe erythema multiforme (Stevens-Johnson syndrome), bullous dermatitis herpetiformis, mycosis fungoides, exfoliative erythroderma
• Kidney disorders such as idiopathic nephrotic syndrome
• Blood disorders such as idiopathic thrombocytopenic purpura, secondary thrombocytopenia, Diamond-Blackfan anemia, pure red cell aplasia, acquired (autoimmune) hemolytic anemia
• Acute exacerbations of gastrointestinal diseases such as ulcerative colitis and regional enteritis
• Certain cancers, such as aggressive lymphomas and acute leukemia
• Acute exacerbations of neurological disorders such as multiple sclerosis
• Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), symptomatic sarcoidosis, fulminating or disseminated pulmonary tuberculosis, idiopathic pulmonary fibrosis, idiopathic eosinophilic pneumonias, hypersensitivity pneumonitis, Pneumocystis carinii pneumonia (PCP) in HIV positive individuals, idiopathic bronchiolitis obliterans with organizing pneumonia, allergic bronchopulmonary aspergillosis
• Ophthalmic diseases (eye conditions) such as uveitis and other inflammatory conditions that do not respond to topical corticosteroids, temporal arteritis, sympathetic ophthalmia
• Rheumatic disorders such as psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, acute gouty arthritis, acute and subacute bursitis, ankylosing spondylitis, epicondylitis, acute nonspecific tenosynovitis
• Autoimmune conditions and inflammatory diseases such as systemic lupus erythematosus, polymyalgia rheumatica, dermatomyositis (polymyositis), Sjogren's syndrome, vasculitis, relapsing polychondritis
• Tuberculosis complications such as meningitis, enlarged mediastinal lymph nodes causing breathing problems, and pleural or pericardial effusion (fluid around the lungs or heart)
• Trichinosis (roundworm infection) with involvement of the brain or heart
• Acute or chronic solid organ rejection

There may be other uses of prednisolone sodium phosphate—your doctor or pharmacist can give you further drug information.

Prednisolone Sodium Phosphate Mechanism of Action

In people with low cortisol hormone levels, prednisolone sodium phosphate replaces the steroid hormone naturally produced by the adrenal glands in the body. This drug helps in the management of inflammatory conditions through its suppressive effects on the immune system.

Prednisolone Sodium Phosphate Doses

Prednisolone sodium phosphate is available as a tablet, orally disintegrating tablet, oral solution, and oral suspension to take by mouth. The usual starting dose ranges between 10 mg to 60 mg of prednisolone, depending on the severity of the condition being treated. The maintenance dose is the lowest dose that can control symptoms.