How should I take progesterone (Prometrium)?

Use progesterone exactly as prescribed. Follow all directions on the prescription label and any medication guides if provided. Never take a larger or smaller amount than the prescribed dose. Ask your doctor or pharmacist if you have any questions or concerns. 

Progesterone is typically intended for use over a short period, from 10 to 12 days, depending on the type of treatment. It is essential to follow your doctor’s dosing instructions carefully. If you also take estrogen, carefully follow the schedule for both medicines together.

Take the oral capsule with a full glass of water. Progesterone may make you drowsy; it is best to take it at night. If you have difficulty swallowing the progesterone capsules, you should take them with a glass of water while standing up. Talk to your doctor or pharmacist if this does not help. 

Apply a thin layer of progesterone cream to clean, dry skin as directed by your doctor. 

Injectable progesterone is given as a shot into one of your muscles. 

Of all dosage forms, progesterone is used on a fixed schedule, and should be taken around the same time every day so you don’t forget a dose. 

Continue to take progesterone as directed, even if your symptoms have improved. Do not stop taking progesterone without talking to your doctor first. 

Keep all doctor and blood test appointments. You should perform breast self-exams for lumps at least monthly while using progesterone. 

Progesterone can increase your risk of developing blood clots. If you’re expecting to be on bed rest after a surgery or any procedure, you will need to stop using progesterone for a short period. Your doctor will tell you when to stop and restart progesterone. Be sure that your surgeons or any healthcare provider who treats you is informed that you use progesterone. 

Missed dose: 
For the oral capsule, topical cream, and vaginal gel/suppository: Take/use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not double the amount or take more than prescribed to make up for the missed dose. Let your doctor know immediately if you have missed more than one dose or are unsure about what to do. 

For the injectable form: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

Storage: Keep the medication in its original container; keep it tightly closed, out of reach of children, pets, and other people. Progesterone should not be shared with anyone like other medications dispensed only with prescriptions. Many people store their medications in the bathroom; this is not recommended due to moisture and heat.

Unused medicine: Like other prescription medications, do not use progesterone after the expiration date. This medication is a prescription drug that is intended for your use only. Unneeded medicines should be disposed of appropriately to prevent children, pets, and other people from getting to them. Your local pharmacy can provide information about medication drug take-back programs. You can also learn more about proper medication disposal.

NOTE: This sheet is a summary and may not contain all possible information. If you have more questions or concerns about progesterone, talk to your pharmacist or doctor to ensure that this information applies to you or your family member.

Discounted prices for progesterone (Prometrium)
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