What are progesterone (Prometrium) side effects?

Signs of progesterone allergy: difficulty breathing, hives (rash on your body), swelling of the face, lips, tongue, or throat—If you experience any of these symptoms, please call 911 or seek emergency medical care at the nearest emergency room (ER). 

You should seek emergency medical care if you experience the following signs:

• Signs of a heart attack: Chest pain or pressure that spreads to your jaw or shoulder; nausea; sweating.
• Signs of a stroke: Sudden numbness or weakness, especially on one side of the body, slurred speech, sudden severe headache, problems with speech or balance.
• Signs of liver injury: Upper stomach pain, nausea, vomiting, severe tiredness, loss of appetite, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes).
• Signs of pulmonary embolism (a blood clot in the lung): Chest pain, wheezing, rapid breathing, sudden unusual cough, and coughing up blood.
• Signs of venous thromboembolism (a blood clot in your leg): Pain, swelling, and warmth or redness in one or both legs. 

Call your doctor immediately if you experience any of the following signs:

• Pain or burning sensation when you urinate
• A breast lump
• Unusual vaginal bleeding
• Severe headache or unusual pain behind your eyes; sudden vision problems
• Severe drowsiness and confusion
• Shortness of breath
• Symptoms of depression - mood fluctuation, loss of interest, extreme fatigue, and sleep problems.

Common side effects of progesterone:

• Dizziness
• Breast tenderness
• Headache
• Mood changes
• Heartburn
• Constipation or diarrhea
• Bloating, indigestion
• Swelling in your hands or feet
• Vaginal discharge
• Hot flashes

Progesterone overdose: Go to the nearest emergency room or call the Poison Help line at 1-800-222-1222. You can find more information at www.poisonhelp.org/help.

Progesterone should be discontinued immediately in overdosage, and supportive treatment is recommended. 

The above list on this site may not include all the possible side effects of progesterone. Speak to your doctor or pharmacist at your local pharmacy if you have persistent side effects or any side effects that are not listed above. You can also report side effects to the Food and Drug Administration (FDA) at 1-800-FDA-1088.

Source: FDA