What is progesterone (Prometrium) used for?

The oral capsule form of progesterone prevents overgrowth of the lining of the uterus in postmenopausal women on estrogen hormone replacement therapy (HRT) to treat menopausal symptoms.

• Lack of menstrual periods in women with low progesterone levels who have not yet reached menopause.
• The injection form can help abnormal uterine bleeding unrelated to menstrual cycle
• The vaginal gel, suppository, and tablet forms are used for adjunct therapy in assisted reproductive therapy (ART) in female infertility. 

There may be other uses of progesterone—your pharmacist or physician can give you further information and assistance

How does progesterone (Prometrium) work?

Progesterone drug products belong to a drug class called progestins. Progestins mimic the mechanism of action of the naturally occurring female hormone progesterone and bind to the progesterone receptors in the body. 

Similar to the hormone progesterone, progestins can change the uterus lining and prevent its overgrowth. The difference is that progestin can be absorbed well by the body, while progesterone is not in oral pill form

What is the dosage of progesterone (Prometrium)?

Prevention of overgrowth of the uterus lining (uterus protection):

Take 200 mg by mouth once daily at bedtime for 12 days in a row. Repeat this direction every 28-day cycle. 

Lack of menstrual period:

Oral capsule:

• Take 400 mg by mouth once daily at bedtime for 10 days. 
• A menstrual cycle (period) should be expected within 7 days of the last capsule you’ve taken.
• Your healthcare provider will instruct you on how often you should take this medication.

Injection:

• Inject 5 mg to 10 mg into a muscle once daily for 6 to 8 days in a row. 
• A menstrual cycle (period) should be expected within 2 to 3 days after the last injection. 
• Your healthcare provider will instruct you on how often you should inject this medication.

Abnormal uterine bleeding unrelated to menstrual cycles:

Injection: 

• Inject 5 mg to 10 mg into a muscle once daily for 6 days in a row. Vaginal bleeding should stop within 6 days.