What side effects may I notice from receiving Prolia?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-bone pain
-breathing problems
-dizziness
-jaw pain, especially after dental work
-redness, blistering, peeling of the skin
-signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine
-signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures
-unusual bleeding or bruising
-unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-constipation
-diarrhea
-headache
-joint pain
-loss of appetite
-muscle pain
-runny nose
-tiredness
-upset stomach

This list may not describe all possible side effects for Prolia. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.