Do not take this medicine with any of the following medications:

-fluvoxamine
-melatonin
-tasimelteon
-viloxazine
This medicine may also interact with the following medications:

-alcohol
-certain medicines for fungal infections like ketoconazole, fluconazole, or itraconazole
-ciprofloxacin
-donepezil
-doxepin
-other medicines for sleep
-rifampin

They need to know if you have any of these conditions:

-history of alcohol or medicine abuse or addiction
-liver disease
-lung or breathing disease (asthma, COPD)
-mental health disease
-sleep apnea
-suicidal thoughts, plans or attempt
-an unusual or allergic reaction to ramelteon, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.
Do not take this medicine unless you are able to stay in bed for a full night (7 to 8 hours) before you must be active again. Do not stand or sit up quickly after taking this medicine, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.
You may still feel drowsy the next day after taking this medicine. Do not drive or do other dangerous activities until you feel fully awake.
After taking this medicine, you may get up out of bed and do an activity that you do not know you are doing. The next morning, you may have no memory of this. Activities include driving a car ("sleep-driving"), making and eating food, talking on the phone, sexual activity, and sleep-walking. Serious injuries have occurred. Stop the medicine and call your doctor right away if you find out you have done any of these activities. Do not take this medicine if you have used alcohol that evening. Do not take it if you have taken another medicine for sleep. The risk of doing these sleep-related activities is higher.
If you or your family notice any changes in your behavior, such as new or worsening depression, thoughts of harming yourself, anxiety, other unusual or disturbing thoughts, or memory loss, call your health care provider right away.
After you stop taking this medicine, you may have trouble falling asleep. This is called rebound insomnia. This problem usually goes away on its own after 1 or 2 nights.

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and moisture. Keep the container tightly closed. Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, take the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.