Do not take this medicine with any of the following medications:
-medicines used to treat erectile dysfunction like sildenafil, tadalafil, and vardenafil
-riociguat

This medicine may also interact with the following medications:
-alteplase
-aspirin
-certain migraine medicines like ergotamine and dihydroergotamine (DHE)
-heparin
-medicines for high blood pressure
-other medicines used to treat angina

They need to know if you have any of these conditions:
-head injury, recent stroke, or bleeding in the brain
-heart disease
-low blood counts, like red cell counts
-low blood pressure
-migraines or recurrent headaches
-an unusual or allergic reaction to nitroglycerin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your doctor or health care professional if you feel your medicine is no longer working.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Close tightly after each use. Throw away any unused medicine after the expiration date.