Do not take this medicine with any of the following medications:

-cisapride
-dronedarone
-pimozide
-thioridazine

This medicine may also interact with the following medications:

-aprepitant
-bosentan
-certain antibiotics like erythromycin or clarithromycin
-certain antivirals for HIV or hepatitis
-certain medicines for depression, anxiety, or psychotic disorders
-certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, and voriconazole
-certain medicines for irregular heart beat like amiodarone, dofetilide, encainide, flecainide, propafenone, quinidine
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-cimetidine
-ciprofloxacin
-conivaptan
-crizotinib
-cyclosporine
-digoxin
-diltiazem
-enzalutamide
-grapefruit juice
-idelalisib
-imatinib
-mifepristone
-mitotane
-modafinil
-other medicines that prolong the QT interval (cause an abnormal heart rhythm)
-rifampin
-St. John''s Wort
-verapamil

They need to know if you have any of these conditions:

-anxiety or panic attacks
-bone problems
-dementia
-depression
-eye disease, vision problems
-heart disease or heart failure
-history of irregular heartbeat
-kidney disease
-liver disease
-trouble sleeping
-an unusual or allergic reaction to entrectinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop. You will need blood work done while you are taking this medicine.

Tell your doctor or health care professional right away if you have any change in your eyesight.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body''s ability to fight infections. Try to avoid being around people who are sick.

Do not become pregnant while taking this medicine or for 5 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 3 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Do not breast-feed an infant while taking this medicine or for 7 days after stopping it.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.