Warnings
Rybelsus Risks, Warnings, and Complications
Rybelsus can cause or worsen health problems, especially in certain high-risk patients. Some of the risks of Rybelsus therapy include:
|
Precautions Before Starting Rybelsus
Tell your healthcare provider if you have ever had an allergic reaction to semaglutide (Rybelsus, Ozempic, Wegovy), any of the active or inactive ingredients in Rybelsus tablets, other GLP-1 receptor agonists, or any other medications. Your pharmacy can give you a list of ingredients. Examples of other GLP-1 receptor agonists include liraglutide (Saxenda, Victoza, in Xultophy), dulaglutide (Trulicity), lixisenatide (Adlyxin, in Soliqua), and exenatide (Bydureon, Byetta).
Give your doctor a complete list of your medications, including prescription drugs, over-the-counter medicines, vitamins, dietary supplements, and herbal products. This can help avoid serious interactions between Rybelsus and your other medications.
Give your doctor a complete medical history. Rybelsus may not be safe for people with certain medical conditions such as kidney disease, pancreatitis, gallbladder disease, or diabetic retinopathy.
Tell your doctor if you are pregnant, could be pregnant, plan to get pregnant, or breastfeeding. Rybelsus may harm the unborn baby if used by pregnant women. Your healthcare provider will recommend stopping Rybelsus at least 2 months before a planned pregnancy. Also, tell your doctor if you are nursing an infant with breast milk.
Precautions During Use of Rybelsus
Keep all your medical and laboratory appointments while on Rybelsus. Your doctor may want to adjust the dose of your other diabetes medications based on your response to Rybelsus (semaglutide). They may also order certain blood tests to monitor you for adverse effects.
Tell your doctor if you have nausea, vomiting, diarrhea, or are unable to drink fluids by mouth, which can lead to dehydration. Also, tell your doctor if you have major changes in your diet, exercise routine, body weight, or have a fever, infection, injuries, surgery, or unusual emotional stress - these conditions can affect your blood sugar levels and how much Rybelsus (semaglutide) you need to take.
Talk to your doctor about how to recognize the signs and symptoms of hypoglycemia (low blood sugar) and what to do if it happens. The risk is higher if you are also taking other diabetes medications.
Call your doctor if you become pregnant while using Rybelsus.
Rybelsus Drug Interactions
Taking Rybelsus with certain other drugs can affect how the medications work. Interactions between medications can also increase the potential risk of serious side effects. For example, other medicines can affect how the body absorbs Rybelsus. Your physician may choose alternative medications rather than prescribe Rybelsus, change the dose of your other medicines, and/or monitor you closely for side effects if there are known interactions between Rybelsus and your other medications. Rybelsus can interact with the following medications:
- Insulin
- Sulfonylureas (oral diabetes medicines), such as glipizide (Glucotrol), glimepiride (Amaryl, in Duetact), chlorpropamide (Diabinese, Glucamide), tolbutamide, glyburide (DiaBeta, Glynase), and tolazamide
- Levothyroxine
This list does not describe all possible Rybelsus interactions. Give your healthcare professionals a complete list of your medications, including prescription drugs, over-the-counter medicines, vitamins, dietary supplements, and herbal products. Also, tell your healthcare provider if you smoke, drink alcohol, or use illegal drugs because some of these substances can cause serious health complications when used with prescription drugs.
SOCIAL