Do not take this medicine with any of the following medications:
-boceprevir
-cyclosporine
-danazol
-gemfibrozil
-medicines for fungal infections like itraconazole, ketoconazole, posaconazole, voriconazole
-medicines for HIV infection
-mifepristone, RU-486
-nefazodone
-red yeast rice
-some antibiotics like clarithromycin, erythromycin, telithromycin
-telaprevir

This medicine may also interact with the following medications:
-alcohol
-amiodarone
-amlodipine
-colchicine
-digoxin
-diltiazem
-dronedarone
-fluconazole
-grapefruit juice
-niacin
-ranolazine
-verapamil
-warfarin

They need to know if you have any of these conditions:

-diabetes
-if you often drink alcohol
-history of stroke
-kidney disease
-liver disease
-muscle aches or weakness
-thyroid disease
-an unusual or allergic reaction to simvastatin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care professional for regular check-ups. You may need regular tests to make sure your liver is working properly.

Your health care professional may tell you to stop taking this medicine if you develop muscle problems. If your muscle problems do not go away after stopping this medicine, contact your health care professional.

Do not become pregnant while taking this medicine. Women should inform their health care professional if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.

If you are going to need surgery or other procedure, tell your doctor that you are using this medicine.

This drug is only part of a total heart-health program. Your doctor or a dietician can suggest a low-cholesterol and low-fat diet to help. Avoid alcohol and smoking, and keep a proper exercise schedule.

This medicine may cause a decrease in Co-Enzyme Q-10. You should make sure that you get enough Co-Enzyme Q-10 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.