This medicine may interact with the following medications:

-alcohol
-antihistamines for allergy, cough, and cold
-certain medicines for anxiety or sleep
-certain medicines for depression like amitriptyline, fluoxetine, sertraline
-certain medicines for seizures like phenobarbital, primidone
-general anesthetics like halothane, isoflurane, methoxyflurane, propofol
-ketamine
-local anesthetics like lidocaine, pramoxine, tetracaine
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-medicines that relax muscles for surgery
-narcotic medicines for pain
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
-psychostimulants like amphetamines, methylphenidate, dexmethylphenidate, modafinil, or armodafinil

They need to know if you have any of these conditions:

-bleeding in the brain
-blood vessel disease (including in the brain, chest, arms, legs, or other areas of the body)
-dementia
-heart disease
-high blood pressure
-history of drug abuse or alcohol abuse problem
-history of head injury
-history of heart attack
-history of irregular heartbeat
-history of stroke
-liver disease
-schizophrenia or other thought disorder
-suicidal thoughts, plans or attempt; a previous suicide by you or a family member
-an unusual or allergic reaction to esketamine, ketamine, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Your condition will be monitored carefully while you are receiving this medicine. Tell your healthcare professional if your symptoms do not start to get better or if they get worse.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until the day following your treatment after a restful sleep. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Avoid alcoholic drinks; they can make you dizzier.
There is a risk for abuse and dependence when using this medicine. Your healthcare provider should check you for signs of abuse and dependence before and during treatment with this medicine. Your healthcare provider can tell you more about the difference between dependence and drug addiction.
Your healthcare provider must monitor you for serious side effects for at least 2 hours after each treatment with this medicine. Your healthcare provider will decide when you are ready to leave the healthcare setting and return home. Tell your healthcare provider right away if you feel like you cannot stay awake or if you feel like you are going to pass out.
Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Women should not breast-feed their infant while taking this medicine. This medicine passes into breast milk and may cause harm to a nursing infant.

This medicine is given in a hospital or clinic and will not be stored at home.