Do not take this medicine with any of the following medicines:

-certain medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
-cidofovir
-ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
-ketorolac
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
This medicine may also interact with the following medications:

-aspirin
-certain medicines for blood pressure, heart disease, irregular heart beat
-certain medicines for depression, anxiety, or psychotic disorders
-certain medicines that treat or prevent blood clots like warfarin, enoxaparin, dalteparin, apixaban, dabigatran, and rivaroxaban
-cyclosporine
-methotrexate
-NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
-pemetrexed
-probenecid

They need to know if you have any of these conditions:

-cigarette smoker
-circulation problems in fingers and toes
-coronary artery bypass graft (CABG) surgery within the past 2 weeks
-diabetes
-drink more than 3 alcohol-containing drinks per day
-heart disease
-high blood pressure
-high cholesterol
-history of irregular heartbeat
-history of stomach bleeding
-history of stroke
-kidney disease
-liver disease
-lung or breathing disease, like asthma
-stomach or intestine problems
-an unusual or allergic reaction to sumatriptan, naproxen, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
Talk to your health care provider if you are pregnant before taking this medicine. Taking this medicine between weeks 20 and 30 of pregnancy may harm your unborn baby. Your health care provider will monitor you closely if you need to take it. After 30 weeks of pregnancy, do not take this medicine.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Do not take other medicines that contain aspirin, ibuprofen, or naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many non-prescription medicines contain aspirin, ibuprofen, or naproxen. Always read labels carefully.
This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. This can happen with no warning and may cause death. Smoking, drinking alcohol, older age, and poor health can also increase risks. Call your healthcare provider right away if you have stomach pain or blood in your vomit or stool.
This medicine does not prevent a heart attack or stroke. This medicine may increase the chance of a heart attack or stroke. The chance may increase the longer you use this medicine or if you have heart disease. If you take aspirin to prevent a heart attack or stroke, talk to your health care provider about using this medicine.
This medicine may increase your risk to bruise or bleed. Call your health care provider if you notice any unusual bleeding.
Tell your healthcare provider right away if you have any change in your eyesight.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your health care provider if the problem does not go away or is severe.
If you take migraine medicines for 10 or more days a month, your migraines may get worse. Keep a diary of headache days and medicine use. Contact your health care provider if your migraine attacks occur more frequently.

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F).
Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, empty the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.