Do not take this medicine with any of the following medications:

-cisapride
-dronedarone
-pimozide
-thioridazine
This medicine may interact with the following medications:

-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide, ziprasidone
-rifampin
-rosuvastatin
-St. John''s Wort
-sulfasalazine
-topotecan

They need to know if you have any of these conditions:

-heart disease
-history of irregular heartbeat
-history of low levels of calcium, magnesium, or potassium in the blood
-lung or breathing disease, like asthma
-QT prolongation
-scarring or thickening of the lungs
-an unusual or allergic reaction to osimertinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor for regular check ups. Report any side effects. Continue your course of treatment unless your doctor tells you to stop. You will need blood work done while you are taking this medicine.
Do not become pregnant while taking this medicine or for 6 weeks after the last dose. Males with female partners of reproductive potential should use effective contraception for 4 months after the last dose. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. This medicine may interfere with the ability to have a child for both men and women. You should talk with your doctor or health care professional if you are concerned about your fertility. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after the last dose.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.