Do not take this medicine with any of the following medications:

-ceritinib
-certain antibiotics like chloramphenicol, clarithromycin, dalfopristin; quinupristin, telithromycin
-certain antiviral medicines for HIV or AIDS like atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir
-certain medicines for fungal infection like ketoconazole, itraconazole, posaconazole, voriconazole
-conivaptan
-idelalisib
-lonafarnib
-mifepristone
-nefazodone
-ribociclib
-tucatinib
This medicine may also interact with the following medications:

-aprepitant
-certain antibiotics like erythromycin, rifampin, and rifapentine
-certain medicines for blood pressure, heart disease, irregular heart beat
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-cyclosporine
-desmopressin
-digoxin
-diuretics
-fluconazole
-grapefruit juice
-hypertonic saline
-St. John''s Wort

They need to know if you have any of these conditions:

-cannot feel if you are thirsty
-dehydration
-history of alcohol abuse or addiction
-kidney disease
-liver disease
-malnutrition
-prostate disease
-an unusual or allergic reaction to tolvaptan, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.
Check with your health care provider if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this drug.
You may need blood work done while you are taking this drug.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, take the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.