Do not take this medicine with any of the following medications:

-cyclosporine
-female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
-glyburide

This medicine may also interact with the following medications:

-amiodarone
-amprenavir
-certain medicines for cholesterol like atorvastatin, lovastatin, and simvastatin
-certain medicines for fungal infections like fluconazole, ketoconazole, and itraconazole
-diltiazem
-erythromycin
-rifampin
-ritonavir

They need to know if you have any of these conditions:

-liver disease
-phenylketonuria
-an unusual or allergic reaction to bosentan, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your doctor or healthcare provider if your symptoms do not start to get better or if they get worse.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your healthcare provider or pharmacist for more information.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your healthcare provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

This medicine has caused reduced sperm counts in some men. This may interfere with the ability to father a child. You should talk to your doctor or healthcare provider if you are concerned about your fertility.

This product may contain aspartame, which is a source of phenylalanine. If you have phenylketonuria (PKU), you may need to contact your healthcare provider for advice.

You may need blood work done while you are taking this medicine.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Divided tablet pieces may be returned to the opened blister and stored under the same conditions for up to 7 days. Throw away any unused medicine after the expiration date.