Do not take this medicine with any of the following medications:

-certain contrast medicines given before X-rays, CT scans, MRI, or other procedures
-dofetilide
-gatifloxacin

This medicine may also interact with the following medications:

-acetazolamide
-alcohol
-bosentan
-certain antivirals for HIV or hepatitis
-certain medicines for blood pressure, heart disease, irregular heartbeat
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-cimetidine
-dichlorphenamide
-digoxin
-diuretics
-female hormones, like estrogens or progestins and birth control pills
-glycopyrrolate
-isoniazid
-lamotrigine
-memantine
-methazolamide
-metoclopramide
-midodrine
-niacin
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
-ranolazine
-rifabutin
-rifampin
-St. Johns Wort
-steroid medicines like prednisone or cortisone
-stimulant medicines for attention disorders, weight loss, or to stay awake
-thyroid medicines
-topiramate
-trospium
-vandetanib
-zonisamide

They need to know if you have any of these conditions:

-anemia
-dehydration
-diabetic ketoacidosis
-diet low in salt
-eating less due to illness, surgery, dieting, or any other reason
-having surgery
-heart disease
-heart failure
-high cholesterol
-history of pancreatitis or pancreas problems
-history of yeast infection of the penis or vagina
-if you often drink alcohol
-infections in the bladder, kidneys, or urinary tract
-kidney disease
-liver disease
-low blood pressure
-on hemodialysis
-polycystic ovary syndrome
-previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat
-problems urinating
-serious infection or injury
-type 1 diabetes
-uncircumcised male
-vomiting
-an unusual or allergic reaction to empagliflozin, linagliptin, metformin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care professional for regular checks on your progress.



This medicine can cause a serious condition in which there is too much acid in the blood. If you develop nausea, vomiting, stomach pain, unusual tiredness, or breathing problems, stop taking this medicine and call your doctor right away. If possible, use a ketone dipstick to check for ketones in your urine.



A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.



Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.



Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.



Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.



Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar.



This medicine may cause ovulation in premenopausal women who do not have regular monthly periods. This may increase your chances of becoming pregnant. You should not take this medicine if you become pregnant or think you may be pregnant. Talk with your doctor or health care professional about your birth control options while taking this medicine. Contact your doctor or health care professional right away if you think you are pregnant.



If you are going to need surgery, a MRI, CT scan, or other procedure, tell your doctor that you are taking this medicine. You may need to stop taking this medicine before the procedure.



Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.



You may see empty tablets in your stool. This is normal.

This medicine may cause a decrease in folic acid and vitamin B12. You should make sure that you get enough vitamins while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.