This medicine may interact with the following medications:

-antiviral medicines for hepatitis, HIV or AIDS
-aprepitant
-bosentan
-calcium channel blockers like diltiazem and verapamil
-certain antibiotics like erythromycin and clarithromycin
-certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, and voriconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-cimetidine
-ciprofloxacin
-crizotinib
-cyclosporine
-dronedarone
-enzalutamide
-fluvoxamine
-grapefruit juice
-imatinib
-mitotane
-modafinil
-rifampin
-St. John''s Wort

They need to know if you have any of these conditions:

-diarrhea
-history of blood clots
-infection (especially a virus infection such as chickenpox, cold sores, or herpes)
-liver disease
-low blood counts, like low white cell, platelet, or red cell counts
-lung or breathing disease, like asthma
-an unusual or allergic reaction to abemaciclib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

You may need blood work done while you are taking this medicine.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

Do not become pregnant while taking this medicine or for at least 3 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Men should inform their doctors if they wish to father a child later. This medicine may lower sperm counts. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 3 weeks after the last dose.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body''s ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Keep out of the reach of children.

Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.