This medicine may interact with the following medications:

-antiviral medicines for HIV or AIDS
-apalutamide
-certain antibiotics like clarithromycin, chloramphenicol, telithromycin, and dalfopristin; quinupristin
-certain antiarrhythmic agents like disopyramide and dofetilide
-certain chemotherapy like doxorubicin, idelalisib, ixabepilone, mitotane, ribociclib, and vinorelbine
-certain calcium channel blockers like isradipine, nisoldipine, and nicardipine
-certain ergot alkaloids like dihydroergotamine and ergotamine
-certain immunosuppressive agents like cyclosporine, sirolimus, and tacrolimus
-certain medicines for fungal infections like itraconazole, ketoconazole, posaconazole, and voriconazole
-certain medicines for seizures like carbamazepine, fosphenytoin/phenytoin, phenobarbital, and primidone
-certain sedatives like midazolam and triazolam
-conivaptan
-eliglustat
-flibanserin
-grapefruit juice
-lomitapide
-lumacaftor; ivacaftor
-mifepristone
-narcotic medicines for pain
-nefazodone
-rifampin
-St.John''s Wort

They need to know if you have any of these conditions:

-liver disease
-tingling or the fingers or toes, or other nerve disorder
-an unusual or allergic reaction to larotrectinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

You may need blood work done while you are taking this medicine.
Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.
Do not become pregnant while taking this medicine or for a least 1 week after stopping it. Women should inform their healthcare professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine or for at least 1 week after stopping it. There is a potential for serious effects to an unborn child. Talk to your healthcare professional for more information.
Do not breast-feed an infant while taking this medicine or for 1 week after stopping it.
This medicine may make it more difficult to get pregnant. Talk to your healthcare professional if you are concerned about your fertility.

Keep out of the reach of children.
Store between 20 and 25 degree C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.