Rybelsus Drug Details (Brand)
Therapeutic Class:
Glucagon-like peptide-1 (GLP-1) receptor agonists
Forms:
Oral tablet
Administration:
By mouth
Therapeutic Uses:
To improve glycemic control and lower blood glucose levels in adults with type 2 diabetes mellitus
Controlled Status:
Not a controlled substance
Rybelsus Drug Class
Rybelsus (rai-bel-sus) belongs to a group of medications called glucagon-like peptide-1 (GLP-1) receptor agonists.
Rybelsus Age Range
Rybelsus (semaglutide) is approved for use in adults. The safety and effectiveness of Rybelsus have not been established in pediatric patients younger than 18 years of age.
Wegovy Drug Details (Brand)
Generic Name:
Semaglutide injection
Availability:
Prescription only
Therapeutic Class:
GLP-1 receptor agonist
Forms:
Injection solution in a prefilled single-use pen
Administration:
Subcutaneous injection
Therapeutic Uses:
- To help with chronic weight management in obese or overweight American adults and children above 12 years of age
- To lower the risk of major cardiovascular events like stroke, heart attack, and death in overweight or obese adults with blood vessel or heart disease
Controlled Status:
Not a controlled substance
Wegovy Drug Class
Wegovy (wee-go-vee) is a glucagon-like-peptide-1 (GLP-1) receptor agonist.
Wegovy Age Range
Wegovy is approved for use in:
- Adults with a body mass index (BMI) of 30 kg/m2 or higher or a BMI of 27 kg/m2 or higher and at least one of the serious health issues related to obesity, such as high blood pressure, type 2 diabetes, or high cholesterol.
- Children 12 years of age and older with a BMI at the 95th percentile or higher.
Ozempic Drug Details (Brand)
Therapeutic Class:
Glucagon-like-peptide-1 (GLP-1) receptor agonist
Forms:
Injection
Administration:
By injection under the skin
Therapeutic Uses:
- To improve glycemic control and lower blood glucose levels in adults with type 2 diabetes mellitus
- To lower the risk of major cardiovascular events and cardiovascular death from stroke and heart attack in people with heart disease and diabetes
Controlled Status:
Not a controlled substance
Ozempic Drug Class
Ozempic (oh zehm puhk) belongs to a group of medications called glucagon-like-peptide-1 (GLP-1) receptor agonists.
Ozempic Age Range
Ozempic is approved for use in adults. It is not known whether Ozempic is safe or effective in children under 18 years of age.
Rybelsus Uses (Brand)
Rybelsus Uses
Rybelsus (oral semaglutide) is used, along with a reduced-calorie diet and exercise, to control blood sugar levels in adults with type 2 diabetes mellitus. Rybelsus is not used to treat type 1 diabetes or diabetic ketoacidosis.
The generic drug semaglutide, which is the active ingredient in Rybelsus, is also available as a once-weekly injectable medicine for people with diabetes under the brand name Ozempic.
Semaglutide has also been FDA-approved for chronic weight management in overweight and obese adults. The semaglutide injection is sold under the trade name Wegovy for weight management.
There may be other uses of Rybelsus—your healthcare professional or pharmacists can give you further Rybelsus drug information.
Rybelsus Mechanism of Action
Rybelsus helps to improve blood sugar by causing the pancreas to release more insulin hormone and the liver to decrease glucagon secretion. These hormones play a key role in controlling blood sugar levels in the body. Rybelsus (semaglutide) also slows the movement of food through the stomach and can increase feelings of fullness, leading to decreased appetite and weight loss.
Rybelsus Doses
Rybelsus comes as 3 mg, 7 mg, and 14 mg tablets. Other dosage forms of semaglutide include Ozempic weekly semaglutide injection for type 2 diabetes and Wegovy weekly semaglutide injection for weight management.
The usual starting dose of Rybelsus (semaglutide oral) is 3 mg once daily for 30 days. The 3-mg dose does not help with glycemic control (blood sugar control) and is for treatment initiation only (to give your body time to adjust to the medicine). After 30 days, the dose of Rybelsus is increased to 7 mg once daily. After another 30 days, the Rybelsus dose can be increased to 14 mg once daily, if needed.
Wegovy Uses (Brand)
Wegovy Uses
Wegovy helps with weight loss when taken along with a lower-calorie diet and increased physical activity. It can also reduce the risk of major adverse cardiovascular events such as heart attack, stroke, and death in overweight and obese individuals with cardiovascular disease.
There may be other uses of Wegovy—your doctor or pharmacist can give you further drug information.
Wegovy Mechanism of Action
Wegovy (semaglutide) is almost identical to a natural hormone in the human body called glucagon-like-peptide-1 (GLP-1). GLP-1 helps to regulate appetite and food intake. Wegovy (semaglutide) binds to and activates GLP-1 receptors in the brain, slows movement of food through the stomach, suppresses appetite, and thereby leads to reduced caloric intake and weight loss. It is unclear how Wegovy lowers the risk of heart attack, stroke, and cardiovascular death in people with established cardiovascular disease.
Wegovy Doses
Wegovy comes in a single-dose, pre-filled, disposable pen for subcutaneous injection (under the skin of the upper arm, abdomen, or thigh) once a week. You should take a Wegovy injection on the same day of the week every week. You can take it at any time of the day without regard to meals.
The dosage strengths of Wegovy pens are 0.25 mg/0.5 mL, 0.5 mg/0.5 mL, 1 mg/0.5 mL, 1.7 mg/0.75 mL, and 2.4 mg/0.75 mL. The dose of Wegovy is gradually increased as follows:
- Weeks 1 through 4: 0.25 mg once weekly
- Weeks 5 through 8: 0.5 mg once weekly
- Weeks 9 through 12: 1 mg once weekly
- Weeks 13 through 16: 1.7 mg once weekly
- Week 17 onwards: 1.7 mg or 2.4 mg once weekly (maintenance dose)
Ozempic Uses (Brand)
Ozempic Uses
Ozempic is a once-weekly non-insulin injectable prescription medicine for adults with type 2 diabetes mellitus. It is used to control blood sugar levels, along with diet and exercise. It is also used to reduce the risk of major adverse cardiovascular events such as heart attack, stroke, and death in people with established cardiovascular disease and diabetes.
Ozempic is not used to treat people with type 1 diabetes or diabetic ketoacidosis. Also, Ozempic cannot be used instead of insulin in people who need insulin for blood sugar control.
There may be other uses of this medicine — your healthcare provider or pharmacist can provide medical advice and give you further Ozempic drug information.
Ozempic Mechanism of Action
Ozempic works by causing the release of more insulin when blood sugar levels are high. Insulin is the hormone that moves glucose from the blood to other organs where it is needed for energy. Ozempic also slows digestion and may lead to decreased appetite and weight loss, which can help with diabetes control.
Ozempic Doses
Ozempic is an injectable prescription medicine available as a pre-filled single-patient-use pen. The Ozempic pen delivers 0.25 mg, 0.5 mg, or 1 mg of semaglutide per injection. The pen is designed for subcutaneous injection (injection under the skin’s surface) and is available as 2 mg/1.5 mL and 4 mg/3 mL.
The usual starting dose of Ozempic is 0.25 mg once a week. After 4 weeks, your doctor may increase the dose to 0.5 mg once a week. After an additional 4 weeks, your Ozempic dose may be increased to 1 mg once a week, depending on blood sugar control. If additional glycemic control is required after at least 4 weeks on the 1 mg dosage, your dosage may be increased to 2 mg once weekly. The maximum dose of Ozempic is 2 mg once a week.
Rybelsus Directions (Brand)
How To Use Rybelsus
Rybelsus comes as an oral tablet to take by mouth. You should take it first thing in the morning on an empty stomach, at least 30 minutes before eating or drinking anything or taking other oral medicines. Take a Rybelsus (semaglutide) tablet with no more than 4 ounces (120 mL) of plain water. Taking medications or eating or drinking within 30 minutes can affect Rybelsus by reducing its absorption and making it less effective.
Eat something 30 minutes after taking your Rybelsus (semaglutide) dose. Waiting more than 30 minutes to eat or drink after taking Rybelsus can lead to increased absorption of Rybelsus. Too much Rybelsus in your body can put you at risk of low blood sugar.
Do not cut, chew, or crush Rybelsus (semaglutide) tablets. If you are on the 14-mg dose of Rybelsus, do not take two of the 7-mg tablets to make a 14-mg dose.
Read the prescription label carefully and take Rybelsus exactly as prescribed. Do not change the dose or dosing frequency without consulting your healthcare provider.
Your doctor will start you on a low dose of Rybelsus and increase the dose every 4 weeks until you are on a maintenance dose that controls your blood sugar levels.
You should know that Rybelsus works alongside a calorie-restricted diet and increased physical activity to help control type 2 diabetes. This medication is not a cure for diabetes. Continue taking Rybelsus even if you feel well and your blood sugar levels are well controlled. Do not stop taking this medication without talking to your doctor.
Missed dose: If you miss a dose of Rybelsus, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take a double dose or extra medicine to make up for a missed dose.
Storage: Store Rybelsus (semaglutide) at room temperature (between 15-30° C or 59-86° F) away from moisture, heat, and direct light in its original container, tightly closed. Do not store medications in the bathroom where they can be exposed to moisture and heat. Keep all medications safely out of reach of children and pets.
Unused medicine: Unused Rybelsus should be disposed of in a way that other people, children, and pets cannot get to them. Do not throw Rybelsus in the trash or flush it down the toilet. The best way to dispose of expired or unneeded Rybelsus is through a drug take-back program or your local waste disposal company. Learn more about proper medication disposal.
NOTE: This sheet is a summary and may not contain all possible Rybelsus drug information. It is for educational purposes only and does not constitute medical advice. If you have questions about Rybelsus, talk to your doctor or pharmacist to ensure you receive proper medical care.
Discounted prices for Rybelsus
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Wegovy Directions (Brand)
How To Use Wegovy
Wegovy (semaglutide) comes as a liquid solution in a prefilled single-use dosing pen for injection subcutaneously (under the skin). It can be injected at any time of the day, with or without food. However, you should inject Wegovy on the same day of the week every week. If you want to change the day of the week that you inject Wegovy, you can do so as long as at least 48 hours (2 days) have passed since your last injection.
Read the prescription label carefully and follow your doctor’s dosing instructions. Use Wegovy exactly as prescribed. Do not change the dose or dosing frequency without your doctor’s approval.
Your doctor will likely start you on a low dose of Wegovy and increase the dose slowly every 4 weeks until you reach a maintenance dose.
You can inject Wegovy in your upper arm, stomach, or thigh areas. Rotate (change) the injection site every week. You may inject Wegovy (semaglutide) and insulin in the same general area of your body, but not immediately next to each other.
Wegovy can help you lose excess weight when used with a reduced-calorie diet and increased physical activity, but it is not a cure for either obesity or being overweight. Continue taking Wegovy as long as your doctor advises. Do not stop treatment without talking to your healthcare provider.
Your doctor or pharmacist will show you how to correctly inject Wegovy. Make sure you understand these instructions. Ask your healthcare providers if you’re unclear about any part of the process.
Wegovy pens that are stored in the refrigerator should be left to warm to room temperature before the injection. Check the injection solution in the Wegovy pen before injecting it. The solution should be clear and colorless without any visible particles. Do not inject Wegovy if the solution appears thickened, cloudy, colored, or has visible solid particles. Also, do not use Wegovy pens that are past the expiration date.
Never reuse a Wegovy pen or share it with others. This is a single-dose disposable pen and should be disposed of in a puncture-resistant container as explained by your doctor and pharmacist.
Missed dose: If you miss a dose of Wegovy, take it as soon as you remember as long as your next dose is at least 48 hours (2 days) away. If there are less than 48 hours left for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take a double dose or extra medicine to make up for a missed dose. If you miss more than two doses of Wegovy, call your doctor. You may need to go back to a lower dose.
Storage: Store Wegovy pens in the refrigerator (36°F to 46°F or 2°C to 8°C). You can also store the pens at room temperature (46°F to 86°F or 8°C to 30°C) in the original carton, as long as the cap hasn’t been opened, for up to 28 days. Do not freeze Wegovy. Do not use Wegovy pens that were frozen and thawed.
Unused medicine: Unused Wegovy should be disposed of in a way that children, other people, and pets cannot get to them. Do not throw Wegovy in the trash or flush it down the toilet. The best way to dispose of expired or unneeded Wegovy is through a drug take-back program. Learn more about proper medication disposal.
NOTE: This medication guide is a summary and may not contain all possible drug information on Wegovy. The information contained here may not be up-to-date. This sheet is for information purposes only. If you have questions about Wegovy, talk to your doctor or pharmacist for medical advice and additional information.
Discounted prices for Wegovy
start at $345.45.
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Ozempic Directions (Brand)
How To Use Ozempic
Ozempic comes as a liquid solution in a pre-filled pen for subcutaneous injection under the skin. This medication is typically injected once a week in the abdomen, thigh, or upper arm. You can administer the Ozempic injection at any time of day, regardless of meal times. However, you should inject Ozempic on the same day of the week every week. If you wish to change the day of the week you inject Ozempic, make sure it has been at least 48 hours (2 days) since your last dose.
You can inject Ozempic in your stomach area, thigh, or upper arm. Rotate (change) the injection site every week. You can inject insulin and Ozempic in the same area, but do not give yourself the injections right next to each other.
If you have stored an Ozempic pen in the refrigerator, allow it to warm to room temperature before using it.
Make sure the Ozempic injection solution is clear, colorless, and free of particles before injecting it. Do not use the medication if it is cloudy, colored, or contains floating particles. Do not use an Ozempic injection pen that is past its expiration date.
Read the manufacturer’s instructions about how to inject Ozempic. If you do not understand the instructions, ask your doctor or pharmacist.
Follow the directions on your prescription label carefully and use Ozempic exactly as directed by your healthcare professional. Do not use more or less of this medicine or use it more or less frequently than prescribed by your doctor.
Your doctor will likely start you on a low dose of Ozempic injection and increase your dose after 4 weeks. Depending on your response to the medicine, they may increase your dose again after an additional 4 weeks.
Never share your Ozempic pen with someone else or reuse a needle. Remove the needle immediately after injecting an Ozempic dose and dispose of it in a protective, sharps, puncture-resistant container.
You should know that Ozempic works in conjunction with diet and exercise to help control diabetes and aid weight loss. However, it is not a cure for diabetes. Continue using Ozempic even if you feel well. Do not stop using this medication without talking to your doctor.
Missed dose: If you forget to take a dose of Ozempic, take the medicine as soon as you remember. You can administer a dose of Ozempic within 5 days of a missed dose. However, if more than 5 days have passed since the missed dose, skip it and take the next dose as scheduled. Do not take two doses together to make up for a missed dose.
Storage:
- You should store unused Ozempic pens in the refrigerator (36-46°F or 2-8°C). Avoid placing the pens near the cooling element of the refrigerator.
- Once an Ozempic pen is in use, you can store it in the refrigerator or at room temperature (59-86°F or 15-30°C).
- Never freeze Ozempic pens. Do not use Ozempic if the medicine has been frozen.
- While traveling, you can store your Ozempic pens at room temperature but do not keep them in the glove compartment or other hot places in a car.
- Note down the date when you first start using an Ozempic pen. Discard the pen after 56 days, even if some medicine is left in the pen.
Unused medicine: Throw away any expired or unused Ozempic. Do not flush the medicine down the toilet. The best way to dispose of medicines is through your local waste disposal company or a medication take-back program. Learn more about proper medication disposal. Your pharmacist or healthcare professional will tell you how to dispose of the puncture-resistant container containing your used needles.
NOTE: This sheet is a summary and may not contain all possible Ozempic drug information. It is for educational purposes only and does not constitute medical advice. If you have questions about Ozempic, ask your doctor or pharmacist to ensure you receive proper medical care.
Discounted prices for Ozempic start at $884.04
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Rybelsus Side Effects (Brand)
Rybelsus Side Effects
Common side effects of Rybelsus are listed below. Tell your doctor if they are severe or do not go away after a few days.
- Nausea
- Vomiting
- Diarrhea
- Stomach pain
- Constipation
- Heartburn
- Burping
- Decreased appetite
Rarely, Rybelsus can cause more serious side effects. Call your doctor right away or seek emergency medical care if you develop:
- Signs and symptoms of a serious allergic reaction (skin rash, itching, hives)
- Swelling of the face, eyes, lips, tongue, or throat
- Difficulty breathing or swallowing
- Persistent stomach pain, with or without vomiting (stomach pain is usually in the upper left or middle part of the stomach and may spread to the back)
- Swelling of the lower legs, ankles, or feet
- Decreased urination
- Vision changes
- Lightheadedness, dizziness, drowsiness, headache, weakness, blurred vision, slurred speech, sweating, confusion, shakiness, jitteriness, fast heartbeat, irritability, anxiety, mood changes, or excessive hunger
The above list may not include all the potential side effects of Rybelsus. Call your doctor if you experience any severe or unusual symptoms. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.
Rybelsus Overdose: In case of an overdose, call your doctor, your local poison control center, or the national poison control center at 1-800-222-1222 immediately. Call 911 if a person has trouble breathing, can’t be awakened, has collapsed, or had a seizure.
Source: FDA
Wegovy Side Effects (Brand)
Wegovy Side Effects
The most common side effects of Wegovy are listed below. Call your doctor for medical advice if they are severe or persistent.
- Stomach pain
- Heartburn
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Burping
Wegovy can also cause more serious side effects. Call your doctor right away or seek emergency medical help if you develop:
- Signs and symptoms of an allergic reaction such as skin rash, hives, itching; swelling of the face, tongue, or throat; or difficulty breathing or swallowing
- Stomach pain in the upper left or middle area that may spread to the back, with or without vomiting
- Swelling of the lower legs, ankles, or feet
- Decreased urination
- Dizziness or fainting
- Rapid heartbeat
- Vision changes
- Upper abdominal pain, yellowing of skin or eyes, fever, light or clay-colored stools
- Lightheadedness, dizziness, drowsiness, sweating, confusion, shakiness, fast heartbeat, headache, blurred vision, slurred speech, hunger, weakness, or mood changes such as irritability, anxiety, or jitteriness
The above list may not include all the potential side effects of Wegovy. Contact your healthcare provider if the side effects are unusual or severe or if they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.
Wegovy Overdose: In case of an overdose of Wegovy, call your doctor immediately. You can also call the national poison control center at 1-800-222-1222. Call 911 if someone has collapsed, is not responding, has stopped breathing, or has had a seizure.
Source: FDA
Ozempic Side Effects (Brand)
Ozempic Side Effects
Some of the common side effects of Ozempic are listed below. Tell your doctor if you have severe adverse gastrointestinal reactions or if they do not go away after a few days.
- Nausea
- Vomiting
- Stomach pain
- Diarrhea
- Constipation
- Heartburn
- Burping
Ozempic can also cause more serious side effects in a small number of people. Call your doctor right away or seek emergency medical care if you experience symptoms such as:
- Persistent severe abdominal pain (severe pain in the upper left or middle part of the abdomen) that may spread to the back (this can occur with or without vomiting) - these can be symptoms of pancreatitis
- Signs and symptoms of serious hypersensitivity reactions (allergic reactions) such as rash, hives, itching, swelling of the face, eyes, mouth, throat, or tongue
- Difficulty breathing or swallowing
- Swelling of legs, ankles, or feet
- Decreased urination
- Muscle cramps
- Vision changes
- Dizziness or fainting
- Rapid heartbeat
The above list may not include all the potential side effects of Ozempic. Call your doctor if you experience any severe or unusual symptoms. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.
Ozempic Overdose: In case of a known or suspected overdose, call your doctor, the local poison control center, or the provincial poison control center immediately. If the person can’t be awakened, has had a seizure, or has trouble breathing, call 911.
NOTE: Ozempic is a prescription drug that is the property of the respective owners and is intended for use only by them. Never share your prescription medication with others or use someone else’s Ozempic.
Source: FDA
Rybelsus Warnings (Brand)
Rybelsus Risks, Warnings, and Complications
Rybelsus can cause or worsen health problems, especially in certain high-risk patients. Some of the risks of Rybelsus therapy include:
|
Precautions Before Starting Rybelsus
Tell your healthcare provider if you have ever had an allergic reaction to semaglutide (Rybelsus, Ozempic, Wegovy), any of the active or inactive ingredients in Rybelsus tablets, other GLP-1 receptor agonists, or any other medications. Your pharmacy can give you a list of ingredients. Examples of other GLP-1 receptor agonists include liraglutide (Saxenda, Victoza, in Xultophy), dulaglutide (Trulicity), lixisenatide (Adlyxin, in Soliqua), and exenatide (Bydureon, Byetta).
Give your doctor a complete list of your medications, including prescription drugs, over-the-counter medicines, vitamins, dietary supplements, and herbal products. This can help avoid serious interactions between Rybelsus and your other medications.
Give your doctor a complete medical history. Rybelsus may not be safe for people with certain medical conditions such as kidney disease, pancreatitis, gallbladder disease, or diabetic retinopathy.
Tell your doctor if you are pregnant, could be pregnant, plan to get pregnant, or breastfeeding. Rybelsus may harm the unborn baby if used by pregnant women. Your healthcare provider will recommend stopping Rybelsus at least 2 months before a planned pregnancy. Also, tell your doctor if you are nursing an infant with breast milk.
Precautions During Use of Rybelsus
Keep all your medical and laboratory appointments while on Rybelsus. Your doctor may want to adjust the dose of your other diabetes medications based on your response to Rybelsus (semaglutide). They may also order certain blood tests to monitor you for adverse effects.
Tell your doctor if you have nausea, vomiting, diarrhea, or are unable to drink fluids by mouth, which can lead to dehydration. Also, tell your doctor if you have major changes in your diet, exercise routine, body weight, or have a fever, infection, injuries, surgery, or unusual emotional stress - these conditions can affect your blood sugar levels and how much Rybelsus (semaglutide) you need to take.
Talk to your doctor about how to recognize the signs and symptoms of hypoglycemia (low blood sugar) and what to do if it happens. The risk is higher if you are also taking other diabetes medications.
Call your doctor if you become pregnant while using Rybelsus.
Rybelsus Drug Interactions
Taking Rybelsus with certain other drugs can affect how the medications work. Interactions between medications can also increase the potential risk of serious side effects. For example, other medicines can affect how the body absorbs Rybelsus. Your physician may choose alternative medications rather than prescribe Rybelsus, change the dose of your other medicines, and/or monitor you closely for side effects if there are known interactions between Rybelsus and your other medications. Rybelsus can interact with the following medications:
- Insulin
- Sulfonylureas (oral diabetes medicines), such as glipizide (Glucotrol), glimepiride (Amaryl, in Duetact), chlorpropamide (Diabinese, Glucamide), tolbutamide, glyburide (DiaBeta, Glynase), and tolazamide
- Levothyroxine
This list does not describe all possible Rybelsus interactions. Give your healthcare professionals a complete list of your medications, including prescription drugs, over-the-counter medicines, vitamins, dietary supplements, and herbal products. Also, tell your healthcare provider if you smoke, drink alcohol, or use illegal drugs because some of these substances can cause serious health complications when used with prescription drugs.
Wegovy Warnings (Brand)
Wegovy Risks, Warnings, and Complications
Wegovy can cause or worsen health problems in certain people. Talk to your doctor or pharmacist about other options for chronic weight management if you are at an increased risk of complications from this drug. Some of the risks of Wegovy use include:
|
Precautions Before Starting Wegovy
Tell your doctor if you have ever had an allergic reaction to semaglutide (Wegovy, Ozempic, Rybelsus), any of the active or inactive ingredients in Wegovy, any other GLP-1 receptor agonist, or any other drugs. Your pharmacy can give you a list of ingredients. Examples of other GLP-1 receptor agonists include dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), exenatide (Byetta, Bydureon), and lixisenatide (Adlyxin, in Soliqua).
Give your doctor and pharmacist a complete list of your medications, including prescription medicines, over-the-counter medicines, dietary supplements, and herbal products. This can help avoid potentially dangerous interactions between your medications.
Give your doctor a complete medical history. Wegovy may not be safe for people with certain medical conditions, such as pancreatitis, gallbladder disease, kidney disease, diabetic retinopathy, or mental health issues. Also, tell your doctor if you have recently had diarrhea, vomiting, or dehydration.
Tell your doctor if you are pregnant, could be pregnant, or are planning a pregnancy soon. Your provider may recommend stopping Wegovy 2 months before a planned pregnancy. Also, tell your doctor if you are breastfeeding.
Talk to your doctor about what to do if you have major changes in your diet or activity levels or have an infection, injury, or unusual mental stress. These conditions can affect your blood sugar levels.
Precautions During Use of Wegovy
Keep all your medical and lab appointments while using Wegovy.
Contact your doctor if you experience any changes in mental health while on Wegovy, including changes in mood and behavior, new or worsening depression, or suicidal ideation or behavior. Members of your household should know how and when to seek help from healthcare professionals if you are unable to do so yourself.
Call your doctor if you become pregnant while on Wegovy.
Tell all your doctors you are on Wegovy, especially before any surgical procedures, including dental treatments.
Wegovy Drug Interactions
Taking Wegovy with certain other drugs can affect how the medications work. Interactions between Wegovy and other medications may increase the risk of severe adverse effects. Your health care professionals may change your dose, monitor you carefully for side effects, or switch you to a different medication if you are at a risk of drug interactions.
Give your doctor and pharmacist a complete list of your medications, including prescription drugs, over-the-counter medications, dietary supplements, and herbal remedies. Also, tell your healthcare professional if you smoke, drink alcohol, or use recreational drugs because some of these substances can cause serious health complications when used with prescription medications.
Ozempic Warnings (Brand)
Ozempic Risks, Warnings, and Complications
Ozempic can cause serious health problems, especially in certain high-risk patients. Some of the risks of Ozempic therapy include:
|
Precautions Before Starting Ozempic
Tell your healthcare provider if you have ever had an allergic reaction to Ozempic (semaglutide), any of the ingredients in Ozempic injections, other medications such as dulaglutide (Trulicity), liraglutide (Saxenda, Victoza), exenatide (Bydureon, Byetta), lixisenatide (Adlyxin, in Soliqua), or any other medications. Your pharmacy can give you a list of ingredients.
Give your healthcare provider a complete medical history. Ozempic may not be right for people with certain medical conditions such as pancreatitis (inflammation of the pancreas), diabetic retinopathy, or kidney disease. Also, tell your healthcare provider if you have recently had nausea, vomiting, diarrhea, or inability to drink fluids by mouth, which can lead to dehydration.
Give your doctor a complete list of all your medications, including prescription drugs, over-the-counter medicines, vitamins, dietary supplements, and herbal products. This can help avoid serious interactions between Ozempic and other drugs.
Tell your doctor if you are pregnant, could be pregnant, plan to get pregnant, or are breastfeeding. You may be advised to stop using Ozempic two months before a planned pregnancy.
Precautions During Use of Ozempic
Keep all your medical and lab appointments while on Ozempic. Your doctor may want to check how well the medication is working to improve glycemic control (blood sugar levels). They may also order certain laboratory tests to monitor your kidney function.
Tell your doctor if there are any big changes in your diet, exercise levels, or weight; if you become dehydrated or if you are eating or drinking less due to an illness that causes nausea, vomiting, and diarrhea; or if you are undergoing surgery, have an infection and/or fever, are experiencing unusual stress, or have suffered an injury. These conditions can lead to fluctuations in blood sugar levels and may affect the amount of Ozempic you need.
Call your doctor if you become pregnant while using Ozempic.
Ozempic Drug Interactions
Taking Ozempic with some other medications can affect how the medications work. Interactions between medications can also increase the risk of serious side effects. Your physician may choose different diabetes medications for you, change the dose or frequency of one or both medicines, and/or closely monitor you for side effects if there are known interactions between Ozempic and your other medications.
Keep in mind that Ozempic can interact with medications you take by mouth and change how your body absorbs these medicines.
There can be potential interactions between Ozempic and the following medications:
- Insulin
- Sulfonylureas (oral diabetes medications), such as glimepiride (Amaryl, in Duetact), glyburide (DiaBeta, Glynase), glipizide (Glucotrol), chlorpropamide (Diabinese, Glucamide), tolbutamide, and tolazamide.
This list does not describe all possible Ozempic interactions. Give your healthcare professionals a complete list of your medications, including prescription drugs, over-the-counter medicines, vitamins, dietary supplements, and herbal products. Also, tell your health care provider if you smoke, drink alcohol, or use illegal drugs because some of these substances can cause serious health complications when used with prescription drugs.
Rybelsus Pros & Cons (Brand)
Rybelsus Pros and Cons
- You only need to take Rybelsus once daily.
- Rybelsus (semaglutide oral) is the only GLP-1 receptor agonist that comes in tablet form (all others need to be injected).
- You can switch from Rybelsus (semaglutide oral) once daily to Ozempic (semaglutide injection) once weekly.
- Taking Rybelsus carries a risk of low blood sugar (hypoglycemia), especially in people who are on other diabetes medications.
- Rybelsus cannot treat type 1 diabetes or diabetic ketoacidosis.
- It is available as a brand name only. There is no low-cost generic currently.
- Rybelsus use has been linked to an increased risk of thyroid cancer called medullary thyroid cancer.
Wegovy Pros & Cons (Brand)
Wegovy Pros and Cons
- Wegovy can help you lose weight faster than diet and exercise alone.
- This medicine reduces cardiovascular risk in obese and overweight individuals.
- You only need to inject Wegovy once a week.
- It is approved for use in children aged 12 and older with a BMI at or above the 95th percentile.
- You have to inject Wegovy.
- It can increase your risk of thyroid cancer, gallbladder disease, kidney injury, and diabetic eye complications.
- You may be at risk of dangerously low blood sugar if you are on insulin or other diabetes medications.
- You cannot take other semaglutide-containing products (Ozempic, Rybelsus) while on Wegovy.
Ozempic Pros & Cons (Brand)
Ozempic Pros and Cons
- You only need to take Ozempic once a week.
- It’s easy to switch your weekly injection day. Make sure the two consecutive doses are at least 48 hours (2 days) apart when switching days.
- Ozempic can help with blood sugar control and weight loss. It can reduce the risk of major cardiovascular events like heart attack and stroke in people at high cardiovascular risk.
- An opened Ozempic pen does not need to be refrigerated - it can be stored at room temperature.
- Ozempic injections must be given under the skin. If you don’t understand the manufacturer’s instructions, ask your pharmacist or healthcare professional to show you how to administer the injections using the correct technique.
- There is a risk of low blood sugar in people who are on other oral diabetes medications and/or insulin as well as Ozempic.
- This medication cannot be used to treat type 1 diabetes or diabetic ketoacidosis.
- There is no low-cost generic version available for Ozempic.
Rybelsus Pharmacist Tips (Brand)
Rybelsus Tips from Pharmacists
Take Rybelsus (oral semaglutide) on an empty stomach first thing in the morning, at least 30 minutes before eating or drinking anything or taking other oral medicines. Eat something 30 minutes after your Rybelsus dose. Take the medicine with no more than 4 ounces of plain water.
You should know that Rybelsus (semaglutide) works in conjunction with a reduced-calorie diet and exercise program.
If you are prescribed 14 mg of Rybelsus daily, take the 14-mg tablet. Do not use two 7-mg tablets instead.
Stomach pain, nausea, vomiting, and diarrhea are common side effects of Rybelsus treatment. Tell your doctor if these side effects are severe or continue after your body has had a chance to adjust to the medicine.
Wegovy Pharmacist Tips (Brand)
Wegovy Tips from Pharmacists
Wegovy injections work best when used alongside a reduced-calorie diet and increased physical activity. Talk to your healthcare provider, licensed nutritionist, and fitness trainer about how to plan healthy, balanced meals and increase exercise safely.
Your doctor will first start you on a low dose of Wegovy and gradually increase the dose. The initial doses of this drug do not cause weight loss. The dose escalation is necessary to give your body time to adjust to the medicine. Do not worry if you don’t notice a reduction in your body weight immediately after starting Wegovy. Follow your doctor’s dosing instructions carefully and continue taking the medication as advised.
Tell your doctor if you have severe gastrointestinal side effects. Your doctor may lower your Wegovy dose.
Store Wegovy pens in the refrigerator. You can also keep unopened pens at room temperature for up to 28 days.
Ozempic Pharmacist Tips (Brand)
Ozempic tips from pharmacists
Ozempic works in conjunction with a healthy diet and exercise.
Ozempic should be injected into the skin of your upper arm, stomach, or thigh. Do not inject this medicine into a vein or muscle.
Inject Ozempic on the same day of the week every week. You can change your injection day, but make sure two successive doses are at least 48 hours apart when making a switch.
Never share your Ozempic pen with others. Do not reuse needles. This can put you at risk of serious infections.
Clean the injection site with an alcohol swab and allow it to dry before injecting Ozempic. Insert the needle into your skin, making sure the dose counter is visible. Press the dose button until the dose counter indicates 0, and you feel or hear a click. Keep the needle in your skin for a count of 6. Then, remove the needle from your skin, and without replacing the cap, remove the needle from the Ozempic pen. Discard the needle in a protective container for sharps. Store this container carefully, out of reach of children and pets.
If you miss a dose of Ozempic, take it as soon as you remember, up to 5 days after the scheduled day. If it is more than 5 days, then skip it and take the next dose. Contact your doctor if you haven’t taken Ozempic for more than 2 weeks.
Store unused Ozempic pens in the refrigerator. Opened pens can be stored at room temperature.
Make a note of the date you start using an Ozempic pen. Discard the pen after 56 days, even if there is some medication remaining in the pen.
Rybelsus Rx Savings Tips (Brand)
Rybelsus Rx Savings Tips
Rybelsus is not currently available in a generic version. The list price of brand name Rybelsus is almost $1,050 per package, although commercially insured patients typically pay less. A BuzzRx Rybelsus coupon can result in big savings on this brand-name drug. With a BuzzRx discount card, savings card, or discount coupons the medication could cost you a fraction of retail prices. Brand name Rybelsus may be under $445.50 for 14 tablets of the 7 mg dose at Walmart, Walgreens, Rite Aid, CVS Pharmacy, and other participating pharmacies with a BuzzRx discount card or free coupon. For the biggest discounts, give the checkout clerk your free Rybelsus discount coupon when you drop off your prescriptions.
Lowest Price for Rybelsus | |
| Brand $445.22 | Generic N/A |
VIEW DISCOUNTS Pricing based on most commonly-filled versions. Select the strength and quantity of your medication for the most accurate pricing. | |
Wegovy Rx Savings Tips (Brand)
Wegovy Rx Savings Tips
Wegovy is a brand name medication, and there is currently no lower-cost generic available. A BuzzRx Wegovy coupon can result in big savings on the drug. With a BuzzRx discount card, savings card, or discount coupons, the medication could cost you a fraction of retail prices. Wegovy may be under $345.45 for one pen injector of the .75 ml of 2.4 mg dose at Walmart, Walgreens, Kroger, CVS Pharmacy, and other participating pharmacies with a BuzzRx discount card or free coupon. For the biggest discounts on Wegovy, give the checkout clerk your BuzzRx Wegovy discount coupon when you drop off your prescriptions.
Lowest Price for Wegovy | |
| Brand $345.45 | Generic N/A |
VIEW DISCOUNTS Pricing based on most commonly-filled versions. Select the strength and quantity of your medication for the most accurate pricing. | |
Ozempic Rx Savings Tips (Brand)
Ozempic Rx savings tips
Ozempic is not currently available in a generic version. Brand name Ozempic can be expensive, costing hundreds of dollars for a month’s supply if your insurance plan does not cover it. However, a BuzzRx Ozempic coupon can result in big savings on the brand-name drug. With a BuzzRx discount card, savings card, or discount coupons, the medication could cost you a fraction of retail prices. Brand name Ozempic may be under $885 for 1 carton of the 1.5 mL pen at Walmart, Walgreens, Kroger, CVS Pharmacy, and other participating pharmacies with a BuzzRx discount card or free coupon. For the biggest discounts on Ozempic, give the checkout clerk your free discount coupon when you drop off your prescriptions.
Lowest Price for Ozempic | |
| Brand $884.04 | Generic NA |
VIEW DISCOUNTS Pricing based on most commonly-filled versions. Select the strength and quantity of your medication for the most accurate pricing. | |
Rybelsus Common Questions (Brand)
Common Questions about Rybelsus
How much does Rybelsus cost without insurance?The cost of Rybelsus without insurance can vary depending on the pharmacy and dosage. On average, patients may pay around $700 to $900 for a 30-day supply, but you can reduce this cost significantly by using the BuzzRx Prescription Discount Card or available Rybelsus coupons. |
Is there a manufacturer coupon for Rybelsus?Yes, a Rybelsus manufacturer coupon may be available, offering discounts on the cost of the medication. Patients can also explore savings options on the BuzzRx site to find other coupons and deals that can be applied at major pharmacies. |
How much does Rybelsus cost at Walmart or CVS?At Walmart, the cost of Rybelsus can vary by dosage, with prices starting at around $800 for the 3 mg dosage. CVS typically has similar pricing, but using a Rybelsus coupon from BuzzRx can help lower the cost at both retailers. |
Can I use a Rybelsus coupon with insurance or Medicare?Yes, patients with insurance or Medicare can often still use BuzzRx coupons to lower their copays or out-of-pocket costs. It’s a great way to ensure you’re getting the best price possible, even if you already have coverage. |
Is Rybelsus insulin?No, Rybelsus is not insulin. It is a GLP-1 receptor agonist that helps the pancreas release more insulin. |
Is Rybelsus a good weight loss pill?Rybelsus is not approved for weight loss. However, Wegovy, which contains the same active ingredient as Rybelsus (semaglutide) is FDA-approved for chronic weight management. Wegovy (semaglutide injection) is taken once a week. |
How much weight will I lose on Rybelsus?Rybelsus is not FDA-approved for weight loss. However, it slows gastric emptying and can lead to decreased appetite, and therefore may cause you to lose weight when used in conjunction with diet and exercise. Placebo-controlled trials have shown that people who took oral semaglutide lost about 15% of their starting body weight. However, the dose of Rybelsus (semaglutide oral) used was significantly higher (50 mg daily) compared to the maintenance doses used to treat type 2 diabetes mellitus (7 mg or 14 mg daily). |
Why is Rybelsus so expensive?Rybelsus is so expensive because it is brand name only and there is no currently no lower cost generic available. A free Rybelsus coupon from BuzzRx can help you save money on your Rybelsus prescription. |
Can I take Rybelsus at night?Rybelsus works best if you take it on an empty stomach first thing in the morning, 30 minutes before eating or drinking anything or taking other medicines by mouth. You should take the Rybelsus tablet with no more than 4 ounces or 120 mL of plain water. Eat something 30 minutes after taking your dose. |
What is the price of Rybelsus without insurance?Without insurance, Rybelsus can be as high as $491.86, but with a free BuzzRx prescription discount coupon, you could pay as low as $445.42 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescription drugs—whether you have insurance or not. |
What is the price of Rybelsus with insurance?Ask your pharmacist or insurance provider for your copay price on Rybelsus—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins. You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for Rybelsus. When using the BuzzRx lookup tool to find the price of your medicine, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not. |
Wegovy Common Questions (Brand)
Common Questions about Wegovy
Who can take Wegovy?Wegovy is approved for use in adults with either obesity or overweight (a body mass index (BMI) of 30 kg/m2 or higher or a BMI of 27 kg/m2 or higher and at least one weight-related health condition). It is also approved for use in children 12 years of age and older who have a BMI at the 95th percentile or higher. |
How much weight can you lose in a month with Wegovy?A clinical trial sponsored by Novo Nordisk, the manufacturer of Wegovy, compared patients who received Wegovy with those who received placebo. The results showed that adults with obesity (with a starting body weight of 232 lbs and BMI of 38.5 kg/m2) who received Wegovy lost approximately 35 lbs or -15% of their body weight on average after taking Wegovy for 2 years. The weight loss of -15% of body weight in the Wegovy group was significantly more than the weight loss of -2.6% of initial body weight in the placebo group. |
How fast will I lose weight on Wegovy?The initial low doses of Wegovy during weeks 1 through 16 are for escalation purposes only and do not result in significant weight loss. You will likely start noticing rapid weight loss once you are on the maintenance dose of Wegovy (1.7 mg or 2.4 mg once a week) from the 17th week onwards. |
Is Wegovy the same as Ozempic?Wegovy and Ozempic contain the same active ingredient, semaglutide. However, Wegovy is for weight loss, and Ozempic is for diabetes, and they are dosed differently. |
Can I take Ozempic for weight loss?Ozempic is not approved for chronic weight management. However, it is sometimes used off-label for this purpose. |
How long can you stay on Wegovy?There is no fixed treatment duration for Wegovy. You will likely take this drug for at least a few months. Your dose will be slowly increased over the first 5 months. Then you can continue taking Wegovy at the maintenance dose as long as you continue losing weight and don’t have bothersome side effects. |
How to inject Wegovy?Wegovy comes in a pre-filled single-dose disposable pen for injection under the skin of your upper arm, thigh, or abdomen. Wash your hands before injecting the medicine. Clean the injection site with soap and water or an alcohol swab. Remove the pen cap when you’re ready to inject. You cannot start and then stop the injection midway and restart. Press the pen into your skin. You will hear two clicks. The first click tells you the injection has started and the second click tells you the medicine is still being injected. Continue holding the pen against your skin until the yellow bar in the pen window is not moving anymore. |
What is the list price of Wegovy?The list price of Wegovy is $367.32 per package. You may be able to obtain Wegovy at a lower price with a BuzzRx prescription discount card or manufacturer coupon. |
What is the price of Wegovy without insurance?Without insurance, Wegovy can be as high as $367.32, but with a free BuzzRx prescription discount coupon, you could pay as low as $345.45 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescription drugs—whether you have insurance or not. |
What is the price of Wegovy with insurance?Ask your pharmacist or insurance provider for your copay price on Wegovy—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins. You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for Wegovy. When using the BuzzRx lookup tool to find the price of your medicine, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not. |
Ozempic Common Questions (Brand)
Common Questions about Ozempic
Is Ozempic for weight loss?Ozempic is not a weight-loss drug. It is an injectable prescription medicine for adults with type 2 diabetes mellitus. However, Ozempic may help with weight loss in people with diabetes. |
Is Ozempic the same as metformin?No, Ozempic is an injectable prescription medicine that belongs to a group of medications called glucagon-like-peptide-1 (GLP-1) receptor agonists. It works by increasing the release of insulin when blood sugar levels are high. Metformin is an oral diabetes medication that belongs to a group of drugs called biguanides. It helps to control the amount of glucose in the blood. |
Can you inject Ozempic at the same time as insulin?Yes, you can inject Ozempic at the same time as insulin and in the same general area of the body. However, you should not mix the two medications and should not give yourself the injections right next to each other. |
Do you have to take Ozempic on the same day every week?Yes, you should take Ozempic on the same day every week. If you wish to change your weekly injection day, you can do so. Make sure there are at least 48 hours between two successive doses when switching days. |
Is Ozempic safe during pregnancy?Ozempic can potentially cause harm to an unborn baby. This medication is not recommended during pregnancy and at least 2 months before a planned pregnancy. Women who are sexually active and are using Ozempic should use contraception. |
What is the price of Ozempic without insurance?Without insurance, Ozempic can be as high as $1050.00, but with a free BuzzRx prescription discount coupon, you could save over $150 and pay $884.04 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, unfortunately, Ozempic is not available as a generic medication. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not. |
What is the price of Ozempic with insurance?Ask your pharmacist or insurance provider for your copay price on Ozempic—copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins. You could save significantly on your prescription medication with a free BuzzRx discount Ozempic coupon. When using the BuzzRx lookup tool to find the price of your medication, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not. |
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