Do not take this medicine with any of the following medications:

-upadacitinib
This medicine may also interact with the following medications:

-antiviral medicines for hepatitis, HIV or AIDS
-azathioprine
-biologic medicines such as abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, ofatumumab, rituximab, sarilumab, secukinumab, tocilizumab, ustekinumab, vedolizumab
-certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, voriconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-cyclosporine
-live vaccines
-medicines that lower your chance of fighting infection
-rifampin
-supplements, such as St. John''s wort
-tacrolimus

They need to know if you have any of these conditions:

-cancer
-diabetes
-heart disease
-high cholesterol
-history of blood clots
-HIV or AIDS
-immune system problems
-infection (especially a viral infection such as chickenpox, cold sores, or herpes)
-kidney disease
-liver disease
-low blood counts, like white cells, platelets, or red blood cells
-lung or breathing disease, like asthma
-organ transplant
-stomach or intestine problems
-tuberculosis, a positive skin test for tuberculosis, or have recently been in close contact with someone who has tuberculosis
-an unusual or allergic reaction to tofacitinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.
You may need blood work while you are taking this medicine.
This medicine may increase your risk of getting an infection. Call your health care provider for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
Avoid taking medicines that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your health care provider. These medicines may hide a fever.
Talk to your health care provider about your risk of cancer. You may be more at risk for certain types of cancer if you take this medicine.
Women should inform their health care provider if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects and harm to an unborn child. Talk to your health care provider for more information.
Do not breast-feed an infant while taking this medicine or for at least 18 hours after stopping it.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original container. Protect from light. Throw away any unused medicine 60 days after opening.