-aspirin and aspirin-like medicines
-certain medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin

They need to know if you have any of these conditions:

-hemophilia
-low platelet counts
-take medicines that treat or prevent blood clots
-an unusual or allergic reaction to collagenase, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Your condition will be monitored carefully while you are receiving this medicine.

If being treated for Dupuytren''s contracture, return to your healthcare provider the day after your hand is injected. In the meantime, do not flex or extend the fingers of your hand that was injected. Do not touch your finger that was injected, and elevate your hand until bedtime. Do not perform activity with the injected hand until you are told that it is OK. Follow any instructions about wearing a splint or performing finger exercises. Also, call your healthcare provider if you get increasing redness or swelling in the hand, if you have numbness or tingling in the treated finger, or if you have trouble bending the finger after the swelling goes down.

If being treated for Peyronie''s disease, you will need to return to your healthcare provider for a manual procedure that will stretch and help straighten your penis. Also, your healthcare provider will show you how to gently stretch your penis at home. Do not resume sexual activity until you are told that it is okay. Follow instructions on when to return for follow-up visits. Immediately call your doctor if you have trouble stretching or straightening your penis, or if you have pain or other concerns.

Immediately call your healthcare provider if you get a fever or chills.

This drug is given in a hospital or clinic and will not be stored at home.