Do not take this medicine with any of the following medications:

-alcohol
-medicines for sleep

This medicine may also interact with the following medications:

-antihistamines for allergy, cough, and cold
-certain medicines for depression, like amitriptyline, fluoxetine, sertraline
-certain medicines for seizures like phenobarbital, primidone
-divalproex sodium
-general anesthetics like halothane, isoflurane, methoxyflurane, propofol
-medicines that relax muscles for surgery
-narcotic medicines for pain
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
-valproate or valproic acid

They need to know if you have any of these conditions:

-depression
-diet low in salt
-heart disease
-high blood pressure
-history of drug or alcohol abuse problem
-if you drink alcohol
-kidney disease
-liver disease
-lung or breathing disease, like sleep apnea
-mental illness
-succinic semialdehyde dehydrogenase deficiency
-suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
-an unusual or allergic reaction to oxybate, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care professional for regular checks on your progress. Tell your healthcare professional if your symptoms do not start to get better or if they get worse. This medicine has a risk of abuse and dependence. Your health care provider will check you for this while you take this medicine.

You may get drowsy or dizzy. This medicine causes sleep very quickly. You should only take your first dose at bedtime, while in bed. The second dose should be taken 2.5 to 4 hours after your first dose. Do not drive, use machinery, or do anything that needs mental alertness for at least 6 hours after taking this drug. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

After taking this medicine, you may get up out of bed and do an activity that you do not know you are doing. The next morning, you may have no memory of this. Activities include driving a car ("sleep-driving"), making and eating food, talking on the phone, sexual activity, and sleep-walking. Serious injuries have occurred. Call your doctor right away if you find out you have done any of these activities. Do not take this medicine if you have used alcohol that evening. Do not take it if you have taken another medicine for sleep. The risk of doing these sleep-related activities is higher.

If you or your family notice any changes in your behavior, such as new or worsening depression, thoughts of harming yourself, anxiety, other unusual or disturbing thoughts, or memory loss, call your healthcare professional right away.

Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep this medicine in the original container. Throw away any unused medicine after the expiration date.

This medicine may cause accidental overdose and death if it is taken by other adults, children, or pets. Flush any unused medicine down the toilet or empty down the sink drain to reduce the chance of harm. Do not use the medicine after the expiration date.

After preparing a dose of this medicine with water, the medicine should be taken within 24 hours or emptied down the sink drain.