Zoloft

Medically Reviewed by HaVy Ngo, Pharm.D.

Last Reviewed: Jun 06, 2022

Pros and Cons


What are the pros and cons of Zoloft (sertraline)?

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  • Zoloft is one of the most effective SSRIs with the fewest side effects.
  • There is less drowsiness with Zoloft than some other antidepressants.
  • Zoloft is one of the antidepressants that can be used (with caution) in pregnant women.

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  • It can take up to 12 weeks for the full effect of Zoloft to develop.
  • Zoloft has interactions with a long list of medications, but this is still less than some other SSRIs.
  • Zoloft is more likely to cause gastrointestinal side effects such as diarrhea than other medications in the same class (SSRIs).