Minocycline

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Aug 05, 2024

Side Effects


Minocycline (Minocin) Side Effects

Possible side effects of minocycline are listed below. Call your doctor for medical advice about side effects if they are severe or if they do not go away in a few days.

  • Nausea, vomiting, diarrhea
  • Vaginal or rectal itching
  • Color changes in the skin, nails, teeth, gums, scars, tears, or urine
  • Hair loss
  • Ringing in the ears
  • Dry mouth
  • Swelling of the tongue
  • Sore throat
  • Muscle pain
  • Mood changes 
  • Numbness, tingling, or prickling sensations in the skin
  • Inflammation of the tip of the penis 

Some of the adverse effects of minocycline are more serious. Call your doctor right away or seek emergency medical attention if you develop the following symptoms:

  • Severe headache
  • Blurred vision, double vision, or vision loss
  • Signs of allergic reactions such as skin rash, hives, itching, blistering, or peeling skin
  • Swelling of the face, eyes, lips, tongue, or throat
  • Shortness of breath 
  • Trouble breathing or swallowing
  • Chest pain
  • Irregular heartbeat
  • Yellowing of the skin or eyes, dark-colored urine, light-colored stools, itching, nausea, vomiting, stomach pain, loss of appetite, tiredness, confusion
  • Blood in the urine
  • Decreased urination
  • Joint pain, swelling, or stiffness
  • Swollen lymph nodes
  • Unusual bleeding or bruising
  • Return of fever and flu like symptoms
  • Stomach pain or cramps, watery or bloody diarrhea, or fever (while taking minocycline or up to 2 months or more after finishing treatment)
  • Convulsions

The above list may not include all the potential side effects of minocycline. Contact your healthcare provider if your side effects are unusual or severe or they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Minocycline (Minocin) Overdose: In case of an overdose of minocycline, call your doctor immediately. You can also call your local poison control center, provincial poison control center, or the national poison control center at 1-800-222-1222. Call 911 or emergency services if a person has collapsed, cannot breathe, has had a seizure, or cannot be awakened. Symptoms of an overdose may include nausea, vomiting, and dizziness.

Source: FDA