Promethazine-Codeine Side Effects

Possible side effects of promethazine with codeine are listed below. Call your doctor for medical advice if they are severe or persist after a few days.

• Drowsiness
• Dizziness or lightheadedness
• Trouble concentrating
• Reduced mental alertness
• Headache
• Dry mouth
• Nausea
• Vomiting
• Constipation

Some of the adverse effects of promethazine with codeine are more serious. Call your doctor right away or seek emergency medical help if you develop the following symptoms:

• Extreme drowsiness
• Slow or irregular breathing
• Bluish tinge to the lips, fingers, or toes
• Chest pain
• Trouble urinating
• Dizziness, nausea, vomiting, loss of appetite, fatigue, weakness, low blood pressure
• Nausea, vomiting, diarrhea, fast heartbeat, high blood pressure, agitation, restlessness, high fever, hallucinations
• High fever, muscle stiffness, mental status changes, fast or irregular pulse, fluctuations in blood pressure, sweating
• An unusual or allergic reaction (skin rash, hives, itching, or swelling)

The above list may not include all the potential side effects of promethazine and codeine. Contact your healthcare provider if your side effects are unusual or severe or if they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Promethazine-codeine Overdose: In case of an overdose of promethazine with codeine, call your doctor immediately. You can also call your local poison control center, provincial poison control center, or the national poison control center at 1-800-222-1222. Overdose symptoms may include slowed, shallow, or stopped breathing, slow heartbeat, excessive drowsiness, narrowed or widened pupils, cold, clammy skin, unresponsiveness, and seizures.

Source: FDA